Publications by authors named "A V Rojo-Garcia"
Objectives: Optimizing rehabilitation strategies for osteoarthritis necessitates a comprehensive understanding of chondrocytes' mechanoresponse in both health and disease, especially in the context of the interplay between loading and key pathways involved in osteoarthritis (OA) development, like canonical Wnt signaling. This study aims to elucidate the role of Wnt signaling in the mechanoresponsiveness of healthy and osteoarthritic human cartilage.
Methods: We used an ex-vivo model involving short-term physiological mechanical loading of human cartilage explants.
Article Synopsis
- Prolonged mechanical loading significantly affects muscle plasticity and mechanosensing in skeletal muscles, particularly during a 14-day tail suspension study on mice.
- The triceps brachii showed a shift from fast to slow muscle fiber types, with enhanced mechanosensor gene and protein levels, alongside changes in transcription factors linked to these fiber types.
- Additionally, indicators of oxidative metabolism increased, suggesting improved muscle oxidative capacity, while markers related to protein synthesis also rose, highlighting the complex adaptive responses of muscles under sustained loading conditions.
Sedentary behavior has become ingrained in our society and has been linked to cardiovascular diseases. Physical inactivity is the main characteristic of sedentary behavior. However, its impact on cardiovascular disease is not clear.
View Article and Find Full Text PDFBackground: Skeletal muscles (SkM) are mechanosensitive, with mechanical unloading resulting in muscle-devastating conditions and altered metabolic properties. However, it remains unexplored whether these atrophic conditions affect SkM mechanosensors and molecular clocks, both crucial for their homeostasis and consequent physiological metabolism.
Methods: We induced SkM atrophy through 14 days of hindlimb suspension (HS) in 10 male C57BL/6J mice and 10 controls (CTR).