Informative value of monitoring of immune status and genome expression in blood leukocytes in psoriatic patients.

Comparative analysis of association with psoriasis before and after treatment of 53K/H2A and 43K/H2A leukocyte protein markers and parameters of leukocyte population (18 indexes) including concentration of peripheral blood lymphocyte subpopulations as markers of the immune status revealed advantages of the former method of patient monitoring for the evaluation of treatment efficacy. The method showed 100% sensitivity and correlation with the dynamics of clinical symptoms. A significant correlation of 53K/H2A parameter with blood content of CD3+, CD4+, CD8+, and CD72+ lymphocytes was established.

[Chemiluminescent analysis of the functional state of cellular and humoral components of neutrophil phagocytosis system in recurrent herpes simplex].

Methods of chemiluminescent analysis of the opsonin-phagocytic system in patients with recurrent herpes simplex and of assessment of in vitro cell sensitivity to immunomodulating agents in the same test are described. The functional activity of neutrophils and opsonizing capacity of the blood sera of patients with herpes simplex infection were found appreciably reduced. Chemiluminescent analysis was found useful for the selection of individual immunocorrecting therapy.

[Venous blood plasma for the serodiagnosis of syphilis].

Microtest and enzyme immunoassay with venous blood plasma, provided the ratio 0.1 ml of 2 percent EDTA and 2 ml of venous blood is observed, are sufficiently sensitive and specific. These results may be useful in practical laboratories, during prophylactic check-ups, etc.

[New approaches to characterizing the immune status of patients with lupus erythematosus using immunoenzyme testing].

A total of 78 patients with various forms of lupus erythematosus (LE) were examined with the use of enzyme immunoassay (EIA) to test the possibility of antibody production in response to neuraminidase, an antigenic stimulant. Positive EIA results were recorded in 54.5% of patients with the integument LE forms and in 58.

[The immune status of scleroderma patients undergoing electroacupuncture].

Examinations of the immune status of 53 patients with local scleroderma (LS) have revealed changes in the cell-mediated (a deficit of T-lymphocyte population in the presence of an unchanged B-lymphocyte count) and humoral immunity (hyperproduction of the circulating immune complexes, of immunoglobulins A and M, the presence of antibodies to fixed lymphocytes). The patients have been treated by electroacupuncture according to an original method, effecting the points that stimulate suppressed immunity. 1-3 courses of treatment have yielded good results in 83% of the patients, mostly with the early stages of the disease.