Designing a potent multivalent epitope vaccine candidate against via reverse vaccinology technique - bioinformatics and immunoinformatic approach.

Scrub typhus is a life-threatening, undifferentiated febrile illness caused by a gram-negative bacterium, . The bacterial strain is a global health concern that should be considered. Despite several years of effort for the development of an effective immunogenic vaccine, no successful licensed vaccine is available.

Loganic Acid Alleviates the Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson's Disease.

The NLRP3 inflammasome signaling cascade activation is a significant contributor to the initiation and progression of Parkinson's disease (PD). Recent evidence supports that targeting NLRP3 inflammasome assembly could be a potential strategy to halt PD progression. The molecular mechanism of the olfactory-brain axis in mediating PD remains elusive.

Neck pain and distance learning: A pain in the neck for university students during COVID-19.

Objective: The shift to online learning during COVID-19 led to increased musculoskeletal discomforts and impacted students' quality of life.Neck pain (NP), once a minor issue, has become more prevalent due to prolonged electronic device use in new learning methods.This study aims to measure the prevalence of NP among University of Sharjah (UOS) students during the COVID-19 online learning period and to investigate the factors that provoked it.

An International Consensus on Evaluation and Management of Idiopathic Genu Valgum: A Modified Delphi Survey.

Background: Idiopathic genu valgum beyond physiological limits may require treatment, which is based on age, growth remaining, and the magnitude of the deformity. There is no consensus on clinical, or radiologic evaluation, indications, and management of idiopathic genu valgum, which can range from observation to surgical treatment using various modalities. If available, such guidelines will help surgeons offer optimal treatment to their patients.