Publications by authors named "A V Ramaraju"
Article Synopsis
- * The ST2/IL-33 pathway promotes immune tolerance by expanding regulatory T cells but also triggers proinflammatory cytokine production for immune defense and tissue repair.
- * Researchers developed improved ST2 inhibitors that effectively reduced ST2 upregulation and IL-1β release in human mast cells, suggesting potential for treating diseases mediated by mast cells.
Article Synopsis
- Microsomal prostaglandin E synthase-1 (mPGES-1) is an enzyme that produces prostaglandin E2 (PGE) during inflammation, making it a targetable pathway for reducing inflammation without the cardiovascular risks linked to long-term COX inhibition.
- The study focuses on thiazole-based mPGES-1 inhibitors that showed effective suppression of PGE production in both human and mouse cell lines, highlighting their potential therapeutic benefits.
- Further evaluations in an inflammation model revealed that one compound significantly reduced proinflammatory markers in the hippocampus, suggesting it could be beneficial in treating neuroinflammatory conditions like epilepsy and stroke, although additional optimization is needed.
Aim: To evaluate the changes in temporomandibular joint (TMJ) vibrations after insertion of the complete denture in edentulous patients.
Settings And Design: An observational in vivo study conducted to evaluate the changes in maximum mouth opening, total integrals, peak amplitude, and peak frequency in TMJ vibrations on the day of complete denture insertion and 6 months of follow up.
Materials And Methods: Twenty patients (male: 12 and female: 8) were selected for the fabrication of balanced complete dentures following conventional procedure.
A novel chemoselective [3 + 2] annulation reaction of easily accessible ketoxime acetate with 2-aryl-3-ethoxycarbonyl pyrroline-4,5-dione has been developed for the synthesis of unknown pyrrolo[2,3-]pyrrole frameworks. This method involves copper-mediated N-O bond cleavage followed by the formation of carbon-carbon and carbon-nitrogen bonds. This operationally simple protocol provides broader functional group compatibility and good yields.
View Article and Find Full Text PDFArticle Synopsis
- A copper-mediated domino condensation reaction combines oxime acetates with ninhydrin to create pyrrolo[2,1-a]isoindolediones through new carbon-carbon and carbon-nitrogen bond formations.
- The reaction allows for a wide variety of oxime acetates to be used, resulting in high yields of the desired products.
- The proposed mechanism involves the formation of an iminium radical through the cleavage of the N-O bond, which then reacts with ninhydrin followed by a rearrangement process.