Study of Antibody-Dependent Reactions of Mast Cells and in a Model of Severe Influenza Infection in Mice.

We investigated the reaction of mouse peritoneal mast cells (MCs) after IgG-containing immune complex introduction using A/H5N1 and A/H1N1pdm09 influenza viruses as antigens. The sera of immune mice served as a source of IgG antibodies. The concentration of histamine in the supernatants was determined at 4 hours after incubation with antisera and virus.

[Age changes in spermogram and fertilizing capacity of spermatosides in persons 26-47 years old.].

The work is devoted to the analysis of age-related changes in human spermatozoa and their functional properties in men aged 26-47 years. The work used ejaculate obtained from 54 men as part of the in vitro fertilization procedure. The patients were divided into three groups (26-29, 30-34 and over 35 years old).

[Immunity, aging and works of V.M.Dilman.].

The review, dedicated to the anniversary of the brilliant gerontologist, endocrinologist and oncologist Vladimir M. Dilman, provides a historical analysis of the hypotheses of immunocooperative interactions, which have been given a prominent place in his original concept of aging. The history of various T-cell populations and sub-populations is reviewed, and their functions are briefly analyzed in relation to age-specific changes in immunity.

Pro-inflammatory modification of cancer cells microsurroundings increases the survival rates for rats with low differentiated malignant glioma of brain.

Rationale: Glioblastoma multiforme (GBM) is one of the most aggressive human brain tumors. The prognosis is unfavorable with a median survival of 15 months. GBM aggressive nature is associated with a special phenotype of cancer cells that develops because of the transforming growth factor β (TGF-β).

Alkaloids of fascaplysin are effective conventional chemotherapeutic drugs, inhibiting the proliferation of C6 glioma cells and causing their death .

Glioblastoma multiforme is an invasive malignant glial brain tumor with a poor prognosis for patients. The primary reasons that lead to the development of treatment resistance are associated with tumor cells infiltrating the brain parenchyma and the specific properties of tumor stem cells. A crucial research area in medical science is the search for effective agents that are able to act on these targets.