Publications by authors named "A V Ovcharenko"
Article Synopsis
- A study evaluated a non-invasive multi-cancer screening method using breath samples to detect breast, lung, prostate, and colorectal cancers in 1,386 participants.
- The method combined trained detection canines and artificial intelligence, resulting in high sensitivity (93.9%) and specificity (94.3%) for identifying cancers.
- The platform showed effective early-stage cancer detection, achieving 94.8% sensitivity for early cancer cases and also identified other malignancies not specifically targeted in its training.
Internal modifications of mRNA have emerged as widespread and versatile regulatory mechanism to control gene expression at the post-transcriptional level. Most of these modifications are methyl groups, making S-adenosyl-L-methionine (SAM) a central metabolic hub. Here we show that metabolic labeling with a clickable metabolic precursor of SAM, propargyl-selenohomocysteine (PSH), enables detection and identification of various methylation sites.
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- - Actinobacteria engage in complex interactions with insects, their food, and pathogens, significantly impacting these relationships.
- - Antibiotics and natural products produced by these bacteria are crucial in these ecological systems, affecting competition and health.
- - The summary reviews studies from January 2016 to August 2022, focusing on the antagonistic properties of insect-associated actinomycetes and their enzyme-inhibiting abilities.
6S RNA, a small non-coding RNA present in almost all bacteria, inhibits transcription via direct binding to RNA polymerase holoenzymes. The mechanism of 6S RNA action was investigated to a large extent in , however, lack of 6S RNA (Δ) was demonstrated to be unfavorable but not essential for cell survival under various growth conditions. In the present study, we revealed, for the first time, a lethal phenotype of the Δ strain in the presence of high concentrations of HO.
View Article and Find Full Text PDFThe RNA methyltransferase (MTase) complex METTL3-METTL14 transfers methyl groups from S-adenosyl-l-methionine (AdoMet) to the N-position of adenosines within its consensus sequence, the DRACH motif (D=A, G, U; R=A, G; H=A, C, U). Interestingly, this MTase complex shows remarkable promiscuity regarding the cosubstrate. This can be exploited to install nonnatural modifications, like clickable or photocaging groups.
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