Publications by authors named "A V Nashchekin"

The umbilical cord is a material that enhances regeneration and is devoid of age-related changes in the extracellular matrix (ECM). The aim of this work was to develop a biodegradable scaffold from a decellularized human umbilical cord (UC-scaffold) to heal full-thickness wounds. Decellularization was performed with 0.

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Cellulose is one of the main renewable polymers whose properties are very attractive in many fields, including biomedical applications. The modification of nanocrystalline cellulose (NCC) opens up the possibility of creating nanomaterials with properties of interest as well as combining them with other biomedical polymers. In this work, we proposed the covalent modification of NCC with amphiphilic polyanions such as modified heparin (Hep) and poly(-glutamic acid) (PGlu).

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Three-dimensional (3D) bioprinting opens up many possibilities for tissue engineering, thanks to its ability to create a three-dimensional environment for cells like an extracellular matrix. However, the use of natural polymers such as silk fibroin in 3D bioprinting faces obstacles such as having a limited printability due to the low viscosity of such solutions. This study addresses these gaps by developing highly viscous, stable, and biocompatible silk fibroin-based inks.

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Article Synopsis
  • Composite collagen gels with hyaluronic acid are developed to help regenerate and fill tissue defects, with phytic acid enhancing their stability and mechanical properties.
  • Phytic acid, a natural antioxidant from plants, acts as a promising cross-linker for collagen but does not promote the self-assembly of collagen molecules.
  • While it improves the stability and elasticity of collagen gels, its presence slightly decreases the viability of mesenchymal stromal cells over time, suggesting potential use for tissue repair after cancerous tumor removal.
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