[Characteristic of bioamine-containing dental pulp structures under normal conditions and in pathology (a luminescence histochemical study)].

Neurotransmitter biogenic amines (BA) are known to be important tissue differentiation inducers and promoters of mutual influence of the epithelial and mesenchymal structures during the process of tooth development in the antenatal period. The aim of this investigation was the study of BA-containing dental pulp structures in the adult humans under normal conditions, and in patients with dental caries and its complications in combination with periodontitis. Using luminescent-histochemical methods, the contents of neurotransmitters (cateholamines, serotonin, histamine) was determined in the dental pulp under normal conditions and in pathology.

[Immunological status of patients with caries and its complications in combination with parodontitis].

Results of complex clinical and immunological study of patients with caries and pulpitis in combination with periodontitis were presented. It was revealed that high intensity of caries and parodontitis combines with significant disturbances in cellular and humoral parts of immune system.

Neuroendocrine cells in the dental pulp in health and disease.

Neuroendocrine cells were identified in human dental pulp by immunohistochemical method using monoclonal antibodies. A population of neuroendocrine cells positively reacting to neuron-specific enolase, synaptophysin, chromogranin A, and stained with paraldehyde-fuchsin, was detected in the subodontoblastic layer of the pulp. Changes in their count, morphology, and function in caries and pulpitis concomitant with periodontitis were proven.

[Identification of the cells expressing neural markers in normal and pathological human dental pulp].

This work presents the results of a immunohistochemical study, performed in order to identify the cells in human dental pulp which express neural markers. Population of cells expressing neuron-specific enolase, synaptophysin, and chromogranin A, which were stained by paraldehyde-fuchsin, was demonstrated in subodontoblastic layer of the dental pulp. Changes the number, morphological and functional characteristics during development of caries and pulpitis in combination with periodontitis are described.

[Comparative study of immunocompetent cells of dental pulp of intact teeth, teeth with carious lesion and its complications combined with parodontitis].

Results of the comparative immunohistochemical study of dental pulp by means of monoclonal antibodies to CD3, CD20, capital ES, CD68 are described. Pulp from the patients with caries, acute and chronic pulpitis in combination with periodontitis on different stages was studied, the qualitative and quantitative feature of dental pulp immune cells--T- and B-lymphocytes and macrophages was determined.