[Organizing the medical care for the COVID-19 patients in non-infectious Moscow hospital: reassignment experience].

Aim: To present the results of work of National Medical Research Center of Treatment and Rehabilitation, reassigned for COVID-19 patients treatment during pandemic. Run-up methodology, procedures and working process organization are detailed.

Materials And Methods: 354 COVID-19 patients were treated from 13.

[Impaired kidney function in patients with atrial fibrillation: practical aspects].

The article focuses on practical aspects of managing patients with a frequently observed combination of atrial fibrillation (AF) and chronic kidney disease (CKD). Based on the authors» own data taken as an example, incidence of different CKD stages in CKD patients was compared with international reports. EchoCG changes were shown to be related with CKD severity.

[The frequency of cerebrovascular disorders in patients with different forms of atrial fibrillation].

Aim: To study the frequency of blood circulation disorders (BCD) in patients with different forms of atrial fibrillation (AF) and its relationship with AF duration and treatment with anticoagulants.

Material And Methods: Medical records and medical history of 1626 patients with non-valvural AF were analyzed in Moscow from 2009 to 2015.

Results: Patients with persistent AF were older and had a higher risk of thromboembolic and hemorrhagic complications.

[Tactics of antihypertensive therapy in patients with hypertonic crisis complicated with hemorrhagic stroke].

Objective: To determine an optimal tactics of antihypertensive therapy in patients with hypertonic crisis complicated with hemorrhagic stroke.

Material And Methods: We examined 86 inpatients, 42 men and 44 women, aged 46-87 years, with hypertonic crisis complicated with hemorrhagic stroke. The severity of neurological deficit, parameters of cardiac output and Kaplan-Meier survival curve based on the level of arterial pressure (AP) were assessed.

Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.

The melanocortin receptors have been implicated as potential targets for a number of important therapeutic indications, including inflammation, sexual dysfunction, and obesity. We identified compound 1, an arylpiperazine attached to the dipeptide H-d-Tic-d-p-Cl-Phe-OH, as a novel melanocortin subtype-4 receptor (MC4R) agonist through iterative directed screening of nonpeptidyl G-protein-coupled receptor biased libraries. Structure-activity relationship (SAR) studies demonstrated that substitutions at the ortho position of the aryl ring improved binding and functional potency.