Publications by authors named "A V Ljubimov"
Article Synopsis
- Pathological tau isoforms, particularly hyperphosphorylated tau at serine 396, and tau oligomers were found in the retinas of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), indicating a potential link between tauopathy and retinal changes.
- The study analyzed retinal cross-sections from 25 patients with MCI or AD and 16 cognitively normal controls, revealing a significant reduction in retinal ganglion cells (RGCs) and increased signs of cell distress in MCI and AD patients compared to controls.
- Findings showed that higher amounts of pS396-tau in RGCs were strongly correlated with decreased RGC integrity and related to severity in cognitive decline, suggesting that retinal
Article Synopsis
- * Researchers analyzed retinal samples from AD patients (both mild cognitive impairment and dementia) and matched controls, finding significant increases in various tau isoforms, particularly in advanced AD cases.
- * Strong correlations were identified between specific retinal tau isoforms and brain pathology, indicating that changes in the retina could reflect the severity of cognitive decline and neurodegeneration in AD patients.
Article Synopsis
- - This study investigates the presence of various pathological tau proteins in the retinas of individuals with early and advanced Alzheimer's disease (AD) and their connection to the severity of the disease.
- - Researchers analyzed retinal and brain samples from 75 donors with conditions ranging from normal cognition to mild cognitive impairment (MCI) and AD, using advanced histopathology and digital profiling methods.
- - The results showed significant increases in multiple tau isoforms in the retinas of AD and MCI patients compared to normal controls, suggesting a correlation between retinal changes and cognitive decline.
Epithelial and stromal/mesenchymal limbal stem cells contribute to corneal homeostasis and cell renewal. Extracellular vesicles (EVs), including exosomes (Exos), can be paracrine mediators of intercellular communication. Previously, we described cargos and regulatory roles of limbal stromal cell (LSC)-derived Exos in non-diabetic (N) and diabetic (DM) limbal epithelial cells (LECs).
View Article and Find Full Text PDF