Kinetics of chlorate formation during ozonation of aqueous chloride solutions.

Chlorate ion ClO is formed as a result of the complex chemical interaction of ozone with chloride ion in aqueous solution. In neutral and basic solutions, chlorate is the main product. In acid solutions, the main product is molecular chlorine Cl, and the yield of chlorate is 50-100 times lower.

The impact of (rs1045642 and rs4148738) and (rs2244613) gene polymorphisms on dabigatran equilibrium peak concentration in patients after total knee arthroplasty.

Background: Non-vitamin K oral anticoagulants (NOACs) are commonly used for prophylaxis of venous thromboembolism (VTE) in orthopedic patients. Despite known safety and high potency of NOACs, potential interactions of NOACs with genetic polymorphisms are poorly understood. Dabigatran etexilate is one of the most commonly prescribed direct thrombin inhibitors for the prevention of VTE.

Dissociation Constants of Perchloric and Sulfuric Acids in Aqueous Solution.

The experimental dissociation constants of strong acids are notoriously ill-defined, and it is necessary to rely on theoretical methods for their evaluation. We present a methodology for the theoretical evaluation of the dissociation constants, and the values of K for perchloric and sulfuric acids have been estimated. It has been shown that the acid dissociation constant K can be expressed as a product of two terms, K = K' × f, where K' is the apparent dissociation constant and f is the infinite dilution activity coefficient of undissociated molecule of acid in liquid solution.

[Clinico-Pharmacological and Clinical Basis of Multiplicity of Intake of Novel Oral Anticoagulants].

In this review we present comparison of pharmacokinetics of novel oral anticoagulants (NOAC) dabigatran, rivaroxaban, apixaban, and edoxaban, principles of selection of a regimen of their dosing for phase III clinical trials in patients with atrial fibrillation. Multiplicity of administration of NOAC depends on required level of anticoagulation, ability to maintain anticoagulation for 24 hours, relationship between minimal and maximal levels of equilibrium concentrations, efficacy and safety. Once a day administration of some drugs of this group is reasonable from positions of clinical pharmacology.

Photochemical oxidation of chloride ion by ozone in acid aqueous solution.

The experimental investigation of chloride ion oxidation under the action of ozone and ultraviolet radiation with wavelength 254 nm in the bulk of acid aqueous solution at pH 0-2 has been performed. Processes of chloride oxidation in these conditions are the same as the chemical reactions in the system O3 - OH - Cl(-)(aq). Despite its importance in the environment and for ozone-based water treatment, this reaction system has not been previously investigated in the bulk solution.