[Change in the production of key cytokines for regulation eosinophilic granulocytes in Opisthorchis felineus invasion].

Opisthorchis invasion is accompanied by the imbalanced lymphocytic subpopulational composition manifested itself as induction of the B-link and, on the contrary, depression of T-lymphocytic populations (CD4+, CD8+), with their weaker helper-suppressor association. The immunocompetent cells were ascertained to show a higher production of TH2 cytokines that had an eosinophil-stumulating effect.

[Opisthorchis felineus (Rivolta, 1884) and Metorchis bilis (Braun, 1890) infections in population of some regions of the Ob River Basin].

The incidence of Opisthorchis felineus (Rivolta, 1884) and Metorchis bilis (Braun, 1890) infections among people living in several regions of the Ob River basin in the West Siberia has been assesed in this work. Our results suggest that Metorchis bilis infection was common in many of the serologically tested people. Moreover, this helminth was obtained from the biliary ducts of humans in autopsy.

[Accumulation of some toxic microelements in liver tissue and helminthes obtained from patients with Opisthorhis felineus (Rivolta, 1884) and Metorchis bilis (Braun, 1890) invasion].

According to some available reports, it is known that there may be an increased accumulation of some micronutrients in the samples of hair and blood. The purpose of the present investigation was to study the general regularities of accumulation of micronutrients in the samples of liver tissue and helminthic bodies obtained from patients with opisthorchiasis who lived in Tomsk and who had different etiological types of Opisthorchis (O. felineus) and Metorchis (M.

[Dysregulation of cytokine production by mononuclear cells of peripheral blood in persistent infection with a virus of tick-borne encephalitis].

Tick-borne encephalitis is accompanied by dysregulation of cytokine production of mononuclear leucocytes of peripheral blood. The changes of production of IFN-r by mononuclear leucocytes of peripheral blood positively correlated with a degree of activity of pathological process and intensity of clinical symptoms of neuroninfection. On the contrary, secretion of IL-12 mononuclears directly correlated with virus persistence in the organism and does not depend on clinical presentation of the disease.

[Immunopathogenetic features of tick-borne encephalitis under long-term viral antigenemia].

The occurrence of chronic tick-borne encephalitis viral antigenemia characterized by the asymptomatic course or minimal clinical manifestations is caused by the virus-immune cell interaction. Cellular immunity was studied in 183 patients with chronic (more than 6-month) tick-borne encephalitis viral antigenemia, by evaluating the immunophenotypic and cytogenetic statuses, structural and functional features, cytokine profile, and peripheral lymphocytic apoptosis. The findings suggest impairments in the cooperation of immunocompetent cells and in the classical scheme of antiviral immunity regulation in tick-borne encephalitis viral persistence due to the changes in lymphocytic structural and functional properties.