[Regulation of catalytic activity and supramolecular structure of angiotensin-converting enzyme in reversed micelles of aerosol OT in octane].

Regulation of the catalytic activity and the supramolecular structure of the angiotensin-converting enzyme isolated from bovine lungs has been studied in a system of reversed micelles of aerosol OT (AOT) in octane. The curve for the dependence of the enzyme catalytic activity on the degree of the surfactant hydration (micellar size) has two maxima at the hydration degrees of [H2O]/[AOT] 27 and 31. Data from velocity sedimentation suggest that depending on the hydration degree, the angiotensin-converting enzyme occurs in the system of reversed micelles in both monomeric and dimeric forms, the latter being catalytically active.