Publications by authors named "A V Laenkholm"
Background And Purpose: We investigated the prognosis of breast cancer (BC) with low expression of human epidermal growth factor receptor 2 (HER2), as previous studies have found varying impacts on survival of HER2-low BC compared with HER2 0 BC (HER2 IHC score of 0). HER2-low is defined as a score of 1+ or 2+ in an immunohistochemical (IHC) assay without HER2 gene amplification.
Materials And Methods: Patients with HER2 0 or HER2-low BC from the national Danish Breast Cancer Group database were examined by multivariable survival analysis in a retrospective noninterventional investigation.
Triple-negative breast cancer (TNBC) is usually aggressive and challenging to treat. With high tumour immunogenicity TNBC patients might benefit from immunotherapy. We evaluated heterogeneous immune profiles of individual tumours in relation to clinical development to identify immune markers and their mutual expression.
View Article and Find Full Text PDFBackground: De-escalation of adjuvant treatment in patients with T1abN0 breast cancer is discussed internationally. Identification of new prognostic factors in these patients may assist this de-escalation. The PAM50 signature and tumor inflammation signature (TIS), Programmed Cell Death Protein 1 (PD-1) and Programmed Cell Death Ligand 1 (PD-L1) signatures are possible prognostic factors for recurrence.
View Article and Find Full Text PDFArticle Synopsis
- The alignment of tissue in whole-slide images (WSI) is essential for both research and clinical purposes, and recent advancements in computing and deep learning have changed how these images are analyzed.
- The ACROBAT challenge was organized to evaluate various WSI registration algorithms using a large dataset of 4,212 WSIs from breast cancer patients, aiming to align tissue stained with different methods.
- The study found that various WSI registration methods can achieve high accuracy and identified specific clinical factors that affect their performance, helping researchers choose and improve their analysis techniques.