[The role of hyperinsulinemia and insulin resistance in development of chronic kidney disease in patients with metabolic syndrome].

Aim: To examine relations between hyperinsulinemia, insulin resistance (IR). components of metabolic syndrome (MS) and predisposition to renal damage,

Material And Methods: A total of 94 MS patients (64 males and 30 females, age 30-67 years, mean age 52 +/- 9 years) entered the study. The examination included measurement of waist and hip circumference, body mass index (BMI), HOMA index, estimation of lipids and immunoreactive insulin concentrations.

[The role of lipid metabolism disorders in kidney disease in metabolic syndrome associated with obesity].

Aim: To study the role of lipid metabolism impairment in renal disease in patients with metabolic syndrome associated with obesity.

Material And Methods: Lipid metabolism was studied in 77 patients with metabolic syndrome (MS) aged from 17 to 63 years (mean age 48 +/- 9 years). Lipid abnormalities were analysed in groups of patients with different degree of obesity: group 1 - body mass index (BMI) 25-29.

[Contribution of obesity to renal lesions in patients with type 2 diabetes mellitus].

Aim: To study of the contribution of obesity to renal lesion in patients with type 2 diabetes mellitus (T2DM).

Subjects And Methods: One hundred and fifty-four patients (62 males and 92 females) with T2DM (mean age 58 +/- 8 years) were examined. The study excluded patients with significant stages of diabetic nephropathy (glomerular filtration rate (GFR) < 60 ml/min; proteinuria more than 2 g/day).

[Effect of sodium oxybutyrate on reflex hemodynamic reactions].

Clinical examination of patients with diseases of the lungs and locomotor system during the surgical treatment and experiments in animals has shown that sodium hydroxybutyrate used as an anesthetizing drug under conditions of the neuroleptic analgesia fails to provide an effective defense against the surgical trauma. This is shown by the instability in the hemodynamic indices, metabolic shifts and the presence of nociceptive viscero-somatic reflexes.