[Cholangiocellular cancer: the state of the problem and ways to improve the results of surgical treatment].

Aim: To improve the outcomes in patients with resectable biliary cancer.

Material And Methods: There were 263 procedures for cholangiocellular carcinoma (CCC) for the period 1998—2017. Adjuvant chemotherapy was performed in 102 (38.

Effects of Fullerene Derivatives on Activity of Ca-ATPase of the Sarcoplasmic Reticulum and cGMP Phosphodiesterase.

We studied the effects of new water-soluble polysubstituted fullerene C60 (PFD) derivatives on activity of Ca-Mg ATPase of the sarcoplasmic reticulum and cGMP phosphodiesterase. All examined fullerene derivatives inhibited activity of both enzymes. For instance, PFD-I, PFD-II, PFD-III, PFD-V, PFD-IX, PFD-X, and PFD-XI in a concentration of 5×10 M completely inhibited hydrolytic and transport functions of Ca-ATPase.

Effects of Nitrosyl Iron Complexes with Thiocarbamide and Its Aliphatic Derivatives on Activities of Ca-ATPase of Sarcoplasmic Reticulum and cGMP Phosphodiesterase.

We studied the effects of water-soluble cationic dinitrosyl iron complexes with thiocarbamide and its aliphatic derivatives, new synthetic analogs of natural NO donors, active centers of nitrosyl [1Fe-2S]proteins, on activities of Ca-ATPase of sarcoplasmic reticulum and cGMP phosphodiesterase. Nitrosyl iron complexes [Fe(CNHS)Cl(NO)][Fe(NO)(CNHS)]Cl (I), [Fe(SC(N(CH))(NO)]Cl (II), [Fe(SC(NH))(NO)Cl×HO (III), and [Fe(SC(NH))(NO)]SO×HO (IV) in a concentration of 10 M completely inhibited the transporting and hydrolytic functions of Ca-ATPase. In a concentration of 10 M, they inhibited active Ca transport by 57±6, 75±8, 80±8, and 85±9% and ATP hydrolysis by 0, 40±4, 48±5, and 38±4%, respectively.

[Surgical strategy for locally-advanced right-sided colonic cancer].

Aim: To present early and remote surgical outcomes in patients with locally-advanced right-sided colonic cancer, invasion of pancreatic head and/or duodenal wall.

Material And Methods: Early and remote surgical outcomes were analyzed in 27 patients who underwent gastropancreatoduodenectomy combined with right-sided hemicolectomy (ileotransversostomy extirpation) for locally-advanced right-sided colonic cancer.

Results: Mean time of surgery was 300 (240-460) minutes, intraoperative blood loss - 2000 (500-7200) ml.

[Total pancreatectomy for pancreatic cancer].

Aim: to determine the indications and to evaluate early and long-term outcomes of total pancreatectomy for pancreatic cancer.

Material And Methods: Treatment of 29 patients who underwent one- and two-stage pancreatectomy for different malignancies was analyzed.

Results: Median of surgery duration and intraoperative blood loss was 280 min and 2200 ml respectively.