[Protection of mice by carbamates cholinesterase inhibitors against poisoning by armin and its dependence on certain physico-chemical indicators].

A series of aminostigmin derivatives with various substituents at nitrogen in the second position of the pyridine ring, has been tested. The efficacy of preventing the death of mice poisoned by armine in five of the seven substances correlates with the constant of the rate of carbamylation of acetylcholinesterase in the in vitro experiments and with the hydrophobic nature. It is suggested that the phenomenon of protection of animals against the toxic effect of organophosphorous compounds involves the "leaving portion" of the molecule of carbamates.

[Radioprotective activity, toxicity and mechanism of action of bis-(beta-dimethyl octyl ammonium ethyl)disulfide].

Disulfide bis-(beta-dimethyl octyl ammonium ethyl) and some of its analogues were shown to have a radioprotective effect. It is suggested that the mechanism of radioprotective action of quaternary ammonium compounds involves both a temporary inhibition of DNA synthesis in radiosensitive tissues and inhibition of oxidative processes in the organism.

[Molecular mechanisms of the radioprotective action of benzothiadiazole derivatives].

The analysis was made of the relationship between the radioprotective efficiency of substituted benzothiadiazoles and their electronic characteristics. The protective effect of these substances was shown to correlate with their ability to participate in the electron transfer. It was established that the protective effect comes into play via the formation of metal complexes in which benzothiadiazole molecules are ligands.