Publications by authors named "A V Klinov"
Article Synopsis
- Patients with severe COVID-19 pneumonia have limited treatment options, and opaganib is an oral medication being researched to help those hospitalized.
- A clinical trial conducted in 57 locations from August 2020 to July 2021 compared opaganib to a placebo over 14 days, focusing on whether patients could stop needing supplemental oxygen by day 14.
- Although the primary results showed no significant general benefit, post-hoc analysis indicated that patients with low oxygen levels at baseline may experience better outcomes with opaganib, including reduced intubation rates and lower mortality, suggesting the need for further studies in this specific group.
The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns. Here we assessed the endocannabinoid profile in the brains of mice with strong characteristics of social dominance and submissiveness. A lipidomics approach was employed to assess the endocannabinoidome in the brains of Dominant (Dom) and Submissive (Sub) mice.
View Article and Find Full Text PDFThe DNA duplex may be locally strongly bent in complexes with proteins, for example, with polymerases or in a nucleosome. At such bends, the DNA helix is locally in the noncanonical forms A (with a narrow major groove and a large amount of north sugars) or C (with a narrow minor groove and a large share of BII phosphates). To model the formation of such complexes by molecular dynamics methods, the force field is required to reproduce these conformational transitions for a naked DNA.
View Article and Find Full Text PDFThis article discusses a molecular simulation of membrane processes for the separation of liquid mixtures during pervaporation. A method for simulating the structure of polyurethane membranes was developed. The method was based on the known mechanisms of the formation of macromolecules from constituent monomers.
View Article and Find Full Text PDFArticle Synopsis
- Researchers developed polyurethane membranes that allow vapor to pass through using aminoethers of boric acid (AEBA), modified with bulk adducts from diphenylol propane diglycidyl ether and ethanolamine (EM).
- These modifications reduced the size of AEBA-EM particles and their viscosity, which helped the membranes become more permeable to vapor.
- The enhanced vapor permeability, which was tripled in the modified polyurethanes, occurs due to reduced cluster size that creates channels for water molecules, improving the membranes' efficiency in dehydrating isopropanol.