Silver N-heterocyclic biscarbene complexes: Potent inhibitors of thioredoxin reductase with anticancer activity in vitro and in vivo.

Silver N-heterocyclic carbene (NHC) complexes are known to form biscarbene species from monocarbene analogs in protic polar solvents. However, the effect of the respective species of silver NHC complexes on their biological activity against bacteria or cancer cells has not been systematically explored, either in vitro or in vivo. The direct and simple conversion of monocarbene silver N-heterocyclic carbene (NHC) halide complexes (NHC)AgX, (X= Cl, Br) 1a/b - 5a/b to their biscarbene analogues (NHC)2AgX 1c/d - 5c/d is reported.

Coordination of Fluorine-Substituted 1,10-Phenanthroline Diphosphonates with Americium(III) and Lanthanides(III): Solvent Extraction, Complexation, XRD, and Theoretical Study.

Hybrid N,O-donor ligands based on 1,10-phenanthroline are a promising class of compounds for processing high-level waste. Here, we synthesized novel phenanthroline-based diphosphonates containing electron-withdrawing fluorine atoms in alkyl substituents. We studied their extraction properties for Am(III) and, for the first time, for the entire series of lanthanides(III).

Synergism of primary and secondary interactions in a crystalline hydrogen peroxide complex with tin.

Despite the significance of HO-metal adducts in catalysis, materials science and biotechnology, the nature of the interactions between HO and metal cations remains elusive and debatable. This is primarily due to the extremely weak coordinating ability of HO, which poses challenges in characterizing and understanding the specific nature of these interactions. Herein, we present an approach to obtain HO-metal complexes that employs neat HO as both solvent and ligand.

[Current approaches to medical-psychological rehabilitation of military personnel of the Russian Federation Armed Forces. (Literature review)].

Improving the medical and psychological rehabilitation system is a priority area for restoring the military personnel's working capacity and combat capabilities after fulfilling special tasks. Changes in the psychoemotional state due to significant psychic and emotional tension can cause mental impairments, which has negative impact not only on military personnel themselves, but also on their combat working capacity. The article presents an overview of forms and methods of medical and medical-psychological rehabilitation used in sanatorium-resort organizations of the Ministry of Defence of the Russian Federation.

A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execution of colorectal cancer cells upon drug-induced activation of mutant KRAS.

RAS is one of the most commonly mutated oncogenes associated with multiple cancer hallmarks. Notably, RAS activation induces intracellular reactive oxygen species (ROS) generation, which we previously demonstrated as a trigger for autophagy-associated execution of mutant KRAS-expressing cancer cells. Here we report that drug (merodantoin; C1)-induced activation of mutant KRAS promotes phospho-AKT S473-dependent ROS-mediated S616 phosphorylation and mitochondrial localization of DNM1L/DRP1 (dynamin 1 like) and cleavage of the fusion-associated protein OPA1 (OPA1 mitochondrial dynamin like GTPase).