Association of GAD1 gene polymorphism rs3749034 with the information processing and cognitive event-related potentials in schizophrenia patients and healthy subjects.

Objective: Glutamic acid decarboxylase, an enzyme in GABA biosynthesis, is encoded by the GAD1 gene, the transcriptional activity of which is affected by the rs3749034 polymorphism. The aim was to investigate the effects of rs3749034 on cognitive event-related potentials (P300) in healthy subjects and schizophrenic patients.

Methods: Determination of rs3749034 polymorphism was performed in 89 healthy volunteers and 109 schizophrenic patients (males).

[Specificity of visual event-related potentials to subthreshold presentation of erotic pictures in pedophilia].

Objective: To study visual event-related potentials (ERPs) associated with presentation of erotic pictures in backward masking condition in order to investigate perception, attention and information processing underlying the initiation and maintenance of abnormal sexual behavior in pedophilia.

Material And Methods: Participants (58 males committed sexual offenses against children) were divided into the pedophilia group (=38) and the control group without disorders of sexual preference (=20). Three types of stimuli were used: neutral pictures of nature (S1), adult heterosexual erotic pictures (S2) and erotic pictures with children (S3).

[Neurophysiological differentiation of personality disorders].

Objective: The neurophysiological objectification of intranosological differentiation of main clusters (schizoid/paranoid and hysterical/emotionally unstable) within the typology of personality disorders (PD), as well as the differentiation of schizoid/paranoid PD and schizophrenia.

Material And Methods: Two groups of patients with PD participated in the study: PD1 - with schizoid/paranoid pattern (=16), and PD2 - with hysterical/emotionally unstable pattern (=18). The data were compared with the control group of healthy volunteers (=86) and the group of schizophrenic patients (Sz, =67).

[Neurophysiological correlates of pedophilia: a study of EEG evoked oscillations].

Objective: To study the changes of evoked EEG oscillations in response to erotic visual stimuli to identify specific patterns in subjects with different variants of pedophilia.

Material And Methods: Forty-eight right-handed male offenders who have committed sexual acts against children participated in the study. Seventeen subjects without paraphilic disorders were included in group 1, 17 subjects with heterosexual pedophilia were included in group 2, and 13 subjects with homosexual pedophilia were included in group 3.

Sensorimotor and sensory gating in depression, anxiety, and their comorbidity.

Objectives: Abnormal attentional and cognitive processes are thought to increase the risk for depression and anxiety. To improve understanding of brain mechanisms of anxiety and depressive disorders and condition of their comorbidity, the study of early attentional processes was provided.

Methods: Participants were patients with depressive (80 s.