Publications by authors named "A V Karpova"
Little is known about the diversity and systematics of nematodes from intertidal sands of the Sea of Japan (East Sea). Here, nematodes of the rare genus Gairleanema and two new species of the family Xyalidae are described and illustrated. Metadesmolaimus innii sp.
View Article and Find Full Text PDFTo study the spatial interactions among cancer and non-cancer cells, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics (ST). This was combined with 48 matched single-nucleus RNA sequencing samples and 22 matched co-detection by indexing (CODEX) samples. To describe tumour structures and habitats, we defined 'tumour microregions' as spatially distinct cancer cell clusters separated by stromal components.
View Article and Find Full Text PDFArticle Synopsis
- Breast cancer (BC) has distinct molecular subtypes influenced by different cell origins, yet the transcriptional networks for these subtypes are not well understood.
- This study utilized advanced techniques on 61 samples from 37 BC patients to reveal how gene expression and chromatin accessibility connect BC subtypes to their likely cells of origin.
- Key transcription factors BHLHE40 and KLF5 were found to play crucial roles in luminal and basal-like tumors, respectively, and exhausted CD8 T cells were linked to immune dysfunction in basal-like BC, showcasing the potential of single-cell level analysis in understanding cancer lineages.
Pediatric antiphospholipid syndrome: is it the same as an adult?
J Matern Fetal Neonatal Med
December 2024
Importance: Antiphospholipid syndrome in neonates and children is a rare, but in some cases life-threatening condition with arterial and/or venous thrombosis and/or non-thrombotic neurological, skin, ophthalmological and other manifestations.
Observations: This review highlights the available information about the features of pediatric APS, including the rare catastrophic form, the differences between pediatric and adult APS, and the role of genetic thrombophilia in APS manifestation.
Conclusions And Relevance: The clinical manifestations and treatment options for APS in children may differ from those in adults, and prescribing therapy can be challenging due to the unique clinical and morphological characteristics of the pediatric patient.
SenNet recommendations for detecting senescent cells in different tissues.
Nat Rev Mol Cell Biol
December 2024
Article Synopsis
- Cellular senescence, once thought to only occur in tissue cultures, is now recognized as playing complex roles in various biological processes across multiple species, including humans.
- Traditional understanding of senescent cells primarily comes from lab studies, but these cells are rare in actual tissues, and fully developed cells can also show signs of senescence.
- The SenNet Biomarkers Working Group has created recommendations for identifying senescent cells in tissues, analyzing literature on markers in mice and humans, and discussing new methods for detection that will assist researchers in the field.