Is Frailty Associated with Worse Outcomes After Major Liver Surgery? An Observational Case-Control Study.

: The rate of morbidity after liver surgery is estimated at 30% and can be even higher when considering higher-risk subgroups of patients. Frailty is believed to better predict surgical outcomes by showcasing the patient's ability to withstand major surgical stress and selecting frail ones. : This is a single-centre, observational case-control study on patients diagnosed with liver malignancies who underwent liver resections between 2013 and 2024.

Eukaryotic initiation factors eIF4F and eIF4B promote translation termination upon closed-loop formation.

Eukaryotic translation initiation factor 4F (eIF4F), comprising subunits eIF4G, eIF4E, and eIF4A, plays a pivotal role in the 48S preinitiation complex assembly and ribosomal scanning. Additionally, eIF4B enhances the helicase activity of eIF4A. eIF4F also interacts with poly (A)-binding protein (PABP) bound to the poly (A) tail of messenger RNA (mRNA), thereby forming a closed-loop structure.

Miniaturized Iontronic Micropipettes for Precise and Dynamic Ionic Modulation of Neuronal and Astrocytic Activity.

The composition of the extracellular milieu can vary significantly under physiological and pathological conditions, thereby altering the functional set point of brain cells. While global changes in the extracellular milieu are known to affect network activity, a detailed understanding of how specific changes in ion species impact individual cells remains elusive. Current modulation methods involve the use of diluted salts, such as KCl, where lack of precise control complicates data interpretation.

Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer.

Harnessing the power of immune system to treat cancer has become a core clinical approach. However, rewiring of intrinsic circuitry by genomic alterations enables tumor cells to escape immune surveillance, leading to therapeutic failure. Uncovering the molecular basis of how tumor mutations induce therapeutic resistance may guide the development of intervention approaches to advance precision immunotherapy.

Doping dependence of the dipolar correlation length scale in metallic SrTiO.

Superconducting domes, ubiquitous across a variety of quantum materials, are often understood as a window in which pairing is favored, opened by the fluctuations of competing orders. Yet, the understanding of how such a window closes is missing. Here, we show that inelastic neutron scattering, by quantifying a length scale associated with the dipoles correlation, ℓ, addresses this issue.