Publications by authors named "A V Hadjinicolaou"
Background And Objectives: There is a paucity of data directly comparing the outcome of surgical techniques available for the treatment of hypothalamic hamartomas (HHs). This study aims to evaluate the safety and efficacy of commonly used surgical approaches in the treatment of HH-related epilepsy.
Methods: A systematic review and individual participant data (IPD) meta-analysis was conducted.
Article Synopsis
- Microsurgical resection of epilepsy-related lesions carries risks of motor impairment, prompting the exploration of less invasive options like MRI-guided laser interstitial thermal therapy (MRgLITT) which has shown improved neurological outcomes.
- A case study of a 17-year-old athlete highlighted the use of advanced tractography techniques to map the corticospinal tract (CST), aiding in presurgical planning and guiding the MRgLITT procedure.
- The integration of CST tractography proved to be effective in enhancing the MRgLITT process, allowing for successful tumor ablation while preserving motor function, although challenges in tractography accuracy and thermal output predictability remain to be addressed.
Background And Objectives: In the United States, many child neurologists (CNs) and neurodevelopmental disability (NDD) specialists who read EEGs in clinical practice had no additional EEG training other than what was received during residency. This practice highlights the importance of ensuring that CN/NDD residents achieve EEG competence before graduation. However, prior survey-based evidence showed that roughly a third of graduating CN residents in the United States do not feel confident interpreting EEGs independently.
View Article and Find Full Text PDFBackground And Objectives: Complete resection of epileptogenic zone is the single most important determinant of favorable seizure outcomes in resective surgery. However, identifying and resecting this zone is challenging in patients harboring diffuse; MRI-occult malformations of cortical development, such as focal cortical dysplasia; or acquired pathology, such as Rasmussen encephalitis. Intraoperative adjuncts that can aid in identifying the lesion and/or epileptogenic zone can optimize the extent of resection and seizure outcome.
View Article and Find Full Text PDFArticle Synopsis
- In 2018, the World Endoscopy Organization (WEO) established standardized methods to calculate post-colonoscopy colorectal cancer rates over three years (PCCRC-3yr), prompting a systematic review to assess global rates and associated risk factors.
- The review analyzed studies from five databases and included eight studies totaling over 220,000 colorectal cancer cases, finding a pooled PCCRC-3yr rate of 7.5% that significantly decreased from 7.9% in 2006 to 6.7% in 2012.
- Higher PCCRC rates were linked to specific risk factors, including inflammatory bowel disease, prior colorectal cancer, proximal cancer location, diverticular disease, and being female, undersc