[The humoral immunity indices and complement functional activity in salmonellosis during the dynamics of the disease].

In 65 patients with bacteriologically confirmed gastrointestinal salmonellosis of moderate severity (41 males and 24 females) the disease in an acute phase was characterized by activation of complement system and specific antibody formation, by a growth in the levels of IgA, G and M. In early convalescence IgA and IgM remained high, IgG in females returned to normal, in males was still high. An inverse correlation was found between functional activity of complement components C3, C4 and C5 and levels of IgM, IgG.

[An experimental study of the safety of a chemical monovalent tableted cholera vaccine in enteral administration].

The safety of experimental chemical cholera monovalent vaccine in tablets, produced by the institute "Microbe" (Saratov, USSR), has been studied. The study has shown that the vaccine, administered to adult rabbits and germ-free suckling rabbits by the enteral route, retains residual toxicity, mainly due to the presence of O-antigen. One or two administrations of 1-2 human doses of this preparation to adult rabbits induce minimal structural changes admissible from the viewpoint of safety.

[The effect of different Yersinia pestis antigens on the cellular link in immunity].

Immunization with live plague vaccine has been shown to give no protection to thymectomized mice from subcutaneous challenge with Y. pestis virulent strain. Under the action of the vaccine or individual Y.

[Use of gnotobiotic animals for the study of the pathogenesis of cholera intoxication].

Germ-free suckling rabbits and minipigs can be recommended as models suitable for the study of different aspects of the pathogenesis of cholera intoxication. In minipigs, individual representatives of intestinal autochthonous microflora produce different effect on the sensitivity of the animals to the toxigenic and choleragenic action of Vibrio cholerae antigen introduced by oral administration, that should also be taken into consideration in the determination of residual toxicity during the trial of new vaccine preparations against cholera.