Publications by authors named "A V Fomin"
Development and Synthesis of Bombesin-Based Radiopharmaceutical Precursors Modified with Knottin.
Sovrem Tekhnologii Med
November 2024
Unlabelled: Bombesin receptors on the cell surface are of great interest as a target for targeted cancer therapy. One of the strategies of targeting bombesin receptors involves the use of tropic short peptides. However, the main limitation for the wide application of peptides as drugs is their low stability due to their sensitivity to extreme conditions of the internal body environment such as temperature and action of enzymes.
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- The study aimed to evaluate the frequency of polymorphisms in genes related to the renin-angiotensin system in COVID-19 patients and how these may correlate with the severity of the disease.* -
- It involved 100 hospitalized patients with confirmed COVID-19, analyzing specific genetic markers related to angiotensinogen, ACE1, and angiotensin II receptors to compare their frequencies with a general population.* -
- Results indicated a higher frequency of specific ACE1 alleles in these patients, with notable differences in the AGTR1 gene that may increase the risk of severe COVID-19, suggesting genetic factors could play a role in disease severity.*
Background: We conducted a study to determine the relationships between perirenal fat (PRF) thickness and urinary levels of monocyte chemoattractant protein-1 (MCP-1) and neutrophil gelatinase-associated lipocalin (NGAL) in patients with hypertension (HTN).
Methods: In 338 HTN patients (aged 63.51±12.
Mesoporous hydroxyapatite (HA) is widely used in various applications, such as the biomedical field, as a catalytic, as a sensor, and many others. The aim of this work was to obtain HA powders by means of chemical precipitation in a medium containing a polymer-polyvinyl alcohol or polyvinylpyrrolidone (PVP)-with concentrations ranging from 0 to 10%. The HA powders were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, atomic emission spectroscopy with inductively coupled plasma, electron paramagnetic resonance, scanning electron microscopy (SEM), and transmission electron microscopy (TEM).
View Article and Find Full Text PDFHydroxyapatite (HA) remains one of the most popular materials for various biomedical applications and its fields of application have been expanding. Lithium (Li) is a promising candidate for modifying the biological behavior of HA. Li is present in trace amounts in the human body as an alkaline and bioelectric material.
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