Publications by authors named "A V Dushkin"
Article Synopsis
- Photodynamic therapy (PDT) effectively targets and destroys cells associated with human papillomavirus (HPV), with a high rate of complete regression observed in both low- and high-squamous intraepithelial lesions among 143 patients studied.* -
- The study demonstrated significant changes in patients' inflammatory responses post-treatment, including increased white blood cell counts and elevated body temperatures, indicating an immune response triggered by the therapy.* -
- Acute inflammation resulting from PDT may enhance its antiviral and antitumor effects by activating the immune system and causing changes in local blood flow in the treated areas.*
We present the findings of assessing the expression levels of extracellular TLR2 and TLR4 and intracellular TLR3 and TLR8 correlating with the severity of clinical manifestations of HPV infection. A total of 199 women took part in a single-center prospective comparative research study on TLR2, TLR3, TLR4 and TLR8 expression in HPV-related cervical lesions. TLRs' mRNA expression was analyzed using real-time reverse transcription polymerase chain reaction (RT-PCR).
View Article and Find Full Text PDFCrocin is a unique water-soluble carotenoid found in crocus and gardenia flowers. Crocin has been shown to have a variety of pharmacological activities, such as antioxidant, anti-cancer, memory improvement, antidepressant, anti-ischemia, blood pressure lowering and aphrodisiac, gene protection and detoxification activities. Due to their amphiphilicity, crocin molecules form concentration-dependent self-associates (micelles) in a water solution.
View Article and Find Full Text PDFBackground: The drug of choice for the treatment of opisthorchiasis caused by trematodes Opisthorchis viverrini and O. felineus is praziquantel (PZQ), but there is a constant search for new anthelmintics, including those of plant origin. Positive results on the use of artemisinin derivatives against O.
View Article and Find Full Text PDFThis article presents two cases of non-melanoma skin cancer treated with photodynamic therapy (PDT). The first case involved a 74-year-old woman with a 4 cm basal cell carcinoma on her right zygomatic region, while the second case involved a 83-year-old woman with a 6 cm squamous cell carcinoma on her left peri‑auricular area. Both patients underwent two sessions of systemic PDT, with chlorin E6 (Photoran) as the photosensitizer, followed by red light illumination.
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