Nanopore Data-Driven T2T Genome Assemblies of Strains.

is a pathogenic fungus that infects flax and causes significant yield losses. In this study, we assembled the genomes of four highly virulent strains using the Oxford Nanopore Technologies (ONT, R10.4.

Extracting information on virus-human interactions and on antiviral compounds based on automated analysis of large text collections.

The development of effective antivirals is of great importance due to the threat associated with the rapid spread of viral infections. The accumulation of data in scientific publications and in databases of biologically active compounds provides an opportunity to extract specific information about interactions between chemicals and their viral and host targets. This information can be used for elucidation of knowledge about potential antiviral activity of chemical compounds, their side effects and toxicities.

Slow magnetic relaxation and strong magnetic coupling in the nitroxyl radical complexes of lanthanide(iii) with diamagnetic ground state (Ln = Lu, Eu).

Radical lanthanide complexes are appealing platforms to investigate the possibility to engineer relevant magnetic couplings between the two magnetic centers by exploiting the strongly donating magnetic orbitals of the radical. In this paper, we report a spectroscopic and magnetic study on [LnRad(NO)], where Ln = Eu or Lu and Rad is the tridentate tripodal nitroxyl radical 4,4-dimethyl-2,2-bis(pyridin-2-yl)-1,3-oxazolidine-3-oxyl. A thorough magnetic investigation by Electron Paramagnetic Resonance (EPR) spectroscopy and magnetometry, fully supported by calculations, allowed us to unravel an unprecedentedly large antiferromagnetic coupling between the Eu and the radical ( = +19.

pH in the vertebrate retina and its naturally occurring and pathological changes.

This review summarizes the existing information on the concentration of H (pH) in vertebrate retinae and its changes due to various reasons. Special features of H homeostasis that make it different from other ions will be discussed, particularly metabolic production of H and buffering. The transretinal distribution of extracellular H concentration ([H]) and its changes under illumination and other conditions will be described in detail, since [H] is more intensively investigated than intracellular pH.

Ten Hypermethylated lncRNA Genes Are Specifically Involved in the Initiation, Progression, and Lymphatic and Peritoneal Metastasis of Epithelial Ovarian Cancer.

Our work aimed to evaluate and differentiate the role of ten lncRNA genes (, , , , , , , , , and ) in the development and progression of epithelial ovarian cancer (EOC). A representative set of clinical samples was used: 140 primary tumors from patients without and with metastases and 59 peritoneal metastases. Using MS-qPCR, we demonstrated an increase in methylation levels of all ten lncRNA genes in tumors compared to normal tissues ( < 0.