[Effect of thyroid and adrenal hormones on the course of hypervitaminosis A and D].

Tests staged on normal and hypophysectomized rats demonstrated thyroxin to potentiate the general toxic effect of ergocalciferol, with final death of the animals. At the same time, the blood calcium content in animals receiving thyroxin decreases under the effect of the latter. Hydrocortisone, while producing no effect on the high calcium content in the blood of the animals receiving ergocalciferol, attenuates the general toxic action of the latter.

[Effect of thyroxine and hydrocortisone on the content of retinol and retinyl palmitate in liver tissue, kidney and blood of rats, loaded with high doses of retinyl acetate].

Administration of hight doses of retinyl acetate into rats caused an increase in content of retinol in liver tissue and kidney and retinyl palmitate in liver tissue, kidney and blood. The simultaneous administration of thyroxine decreased the accumulation of retinol and retinyl palmitate in liver tissue. At the same time, in kidney content of retinol was increased but content of retinol and retinyl palmitate in blood and retinyl palmitate in kidney did not differ from the values estimated in the control group.