Publications by authors named "A V Chugunova"
tRNA genes exist in multiple copies in the genome of all organisms across the three domains of life. Besides the sequence differences across tRNA copies, extensive post-transcriptional modification adds a further layer to tRNA diversification. Whilst the crucial role of tRNAs as adapter molecules in protein translation is well established, whether all tRNAs are actually expressed, and whether the differences across isodecoders play any regulatory role is only recently being uncovered.
View Article and Find Full Text PDFRibosomes are produced in large quantities during oogenesis and are stored in the egg. However, the egg and early embryo are translationally repressed. Here, using mass spectrometry and cryo-electron microscopy analyses of ribosomes isolated from zebrafish (Danio rerio) and Xenopus laevis eggs and embryos, we provide molecular evidence that ribosomes transition from a dormant state to an active state during the first hours of embryogenesis.
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- Williams-Beuren syndrome (WBS) is caused by a deletion of genes on chromosome 7, leading to a variety of health issues due to protein malfunction.
- The role of the protein methyltransferase WBSCR27 in WBS remains unclear, prompting researchers to create gene knockout mouse cell lines to identify its methylation targets.
- Through structural analysis, they discovered that WBSCR27 has a characteristic Class I methyltransferase structure, and binding to S-adenosyl-L-homocysteine (SAH) helps form a substrate binding site, suggesting areas for future investigation.
Cell fate transitions depend on balanced rewiring of transcription and translation programs to mediate ordered developmental progression. Components of the nonsense-mediated mRNA decay (NMD) pathway have been implicated in regulating embryonic stem cell (ESC) differentiation, but the exact mechanism is unclear. Here we show that NMD controls expression levels of the translation initiation factor and its premature termination codon-encoding isoform ( ).
View Article and Find Full Text PDFBackground: The problem of pregnancy losses and infertility in autoimmune pathology is one of the most urgent problems of modern reproductive medicine. Antiphospholipid antibodies (aPL) are very often connected with reproductive failures such as miscarriage, antenatal fetal death, preeclampsia and even infertility and failure of fertilization (IVF) program.
Aim: To evaluate the difference in immune status of aPL-positive women with infertility compared to healthy women and explain the possible mechanism of pathological effects of aPL, a correlation analysis between the level of aPL and the lymphocytes subpopulation was performed.