Targeting CD45 by gene-edited CAR T cells for leukemia eradication and hematopoietic stem cell transplantation preconditioning.

Hematopoietic stem cell transplantation (HSCT) is widely used to treat patients with life-threatening hematologic and immune system disorders. Current nontargeted chemo-/radiotherapy conditioning regimens cause tissue injury and induce an array of immediate and delayed adverse effects, limiting the application of this life-saving treatment. The growing demand to replace canonical conditioning regimens has led to the development of alternative approaches, such as antibody-drug conjugates, naked antibodies, and CAR T cells.

Tungsten Diselenide Nanoparticles Produced via Femtosecond Ablation for SERS and Theranostics Applications.

Due to their high refractive index, record optical anisotropy and a set of excitonic transitions in visible range at a room temperature, transition metal dichalcogenides have gained much attention. Here, we adapted a femtosecond laser ablation for the synthesis of WSe nanoparticles (NPs) with diameters from 5 to 150 nm, which conserve the crystalline structure of the original bulk crystal. This method was chosen due to its inherently substrate-additive-free nature and a high output level.

Dual-Wavelength On-Chip Integrated Metalens for Epi-Fluorescence Single-Molecule Sensing.

Single-molecule fluorescence spectroscopy offers unique capabilities for the low-concentration sensing and probing of molecular dynmics. However, employing such a methodology for versatile sensing and diagnostics under point-of-care demands device miniaturization to lab-on-a-chip size. In this study, we numerically design metalenses with high numerical aperture (NA = 1.

Spatially inhomogeneous inverse Faraday effect provides tunable nonthermal excitation of exchange dominated spin waves.

We demonstrate optical nonthermal excitation of exchange dominated spin waves of different orders in a magnetophotonic crystal. The magnetophotonic structure consists of a thin magnetic film and a Bragg stack of nonmagnetic layers to provide a proper nonuniform interference pattern of the inverse Faraday effect induced by light in the magnetic layer. We found a phenomenon of the pronounced phase slippage of the inverse Faraday effect distribution when the pump wavelength is within the photonic band gap of the structure.