[Nitric oxide synthase and apoptosis activity in chondrocytes of articular cartilage in posttraumatic knee instability].

The dynamics of nitric oxide synthase (NOS) and apoptosis activity was studied in the in chondrocytes of articular cartilage of the patients with posttraumatic knee instability. Statistically significant increase of chondrocyte NOS activity was detected in the earliest period after the trauma (1.5 months).

Nitroxide synthase activity as a marker of early stages of experimental cartilage dysmetabolism.

Time course of nitroxide synthase activity in the knee joint cartilage was studied in animals with experimental anterior instability of the knee joint. A significant increase in nitroxide synthase activity in chondrocytes was paralleled by a progressive decrease in glycosaminoglycan content in the cartilaginous matrix and subsequent destruction of the cartilage cytoarchitectonics.