[SQUALENE: PHYSIOLOGICAL AND PHARMACOLOGICAL PROPERTIES].

The review of literature demonstrates that squalene, known to most experts as an intermediate product in the synthesis of cholesterol, has several pharmacological properties including hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity. Squalene is effective in the treatment of diabetes mellitus type 2 and can potentiate the activity of some antitumor (antiblastoma) preparations and reduce their undesired side effects. This bioactive substance has low toxicity and, in therapeutic doses, does not produce any damaging action on the human organism.

[Pharmacological correction of the ulcerogenic action of NSAIDs in rats].

Experimental preclinical investigations on a group of 90 white outbred male rats showed that preliminary preventive introduction of procaine (novocaine, 1.07 mg/kg) or taurine (7.14 mg/kg) during 7 days before the administration of ketorolak trometamine significantly reduced the number of erosive-ulcerous lesions (by more than 87%, p < 0.

[Drug-induced liver damage and the problem of its pharmacological correction].

This review summarizes data on the pathogenesis and diagnostics of drug-induced liver damage. Special attention is paid to the role of individual genetically determined characteristics of drug metabolism in the development of this pathology. Results of experimental and clinical studies of the efficacy of hepatoprotectors in the treatment and prevention of the drug-induced hepatotoxicity are generalized.

[Humic substances: pharmacological properties, mechanisms of action, and prospects for use in medicine].

In recent years, the group of natural compounds called humic substances has drawn increasing interest of researchers both in, Russia and abroad. The properties of humic substances were studied and attempts of creating related medical preparations were undertaken. The article summarizes and reviews information about the pharmacological properties of humic substances and their possible mechanisms of action, analyzes relationships and separates the primary and secondary factors, and assesses prospects of using humic substances in medicine.