Publications by authors named "A V Buemi"
: Induction therapy with basiliximab is recommended in kidney transplant (KT) recipients with a low immunological risk (LIR) profile. Whether basiliximab is associated with a decreased risk of acute rejection (AR) and graft loss is controversial. : In our institution, LIR patients (absence of anti-HLA antibodies before KT) are inducted with basiliximab in case of living-donor KT, while deceased-donor KT recipients receive no induction.
View Article and Find Full Text PDFKidney transplantation (KT) is the best treatment for patients with kidney failure, associated with improved survival and quality of life compared with maintenance dialysis. However, despite constant improvements in the assessment and management of the alloimmune response, KT patients frequently demonstrate a reduced estimated glomerular filtration rate. Therefore, the usual complications of chronic kidney disease (CKD), such as anemia, hypertension, metabolic acidosis, hyperkalemia, or persistent secondary hyperparathyroidism, are highly prevalent after KT.
View Article and Find Full Text PDFIntroduction: Etelcalcetide is an i.v. calcimimetic agent, effectively reducing parathyroid hormone levels in patients on maintenance hemodialysis (HD).
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- This study evaluated three pancreas preservation techniques: static cold storage, hypothermic machine perfusion (HMP), and oxygenated HMP, focusing on their effects on islet transplantation.
- The methodology involved using discarded human pancreas organs from both brain death and circulatory death donors, comparing outcomes in islet yield, function, histology, and other factors.
- Results indicated no significant differences in islet functionality or histology among the preservation methods, although DCD organs showed higher islet purity in the HMP group, highlighting the need for more research in this area.
Donor- and isolation-related predictive factors of secretory function of cultured human islets.
Front Endocrinol (Lausanne)
March 2024
Background And Aims: Human islet preparations designated for research exhibit diverse insulin-secretory profiles. This study aims to assess the impact of donor- and isolation-related factors on islet secretory function.
Methods: A retrospective analysis of 46 isolations from 23 pancreata discarded for clinical transplantation was conducted.