Publications by authors named "A V Bocharova"
Metabolic syndrome (MetS) is common among schizophrenia patients, and one of MetS's causes may be an imbalance in nitric oxide regulation. In this study, we examined associations of three polymorphic variants of the nitric oxide synthase 1 adapter protein () gene with MetS in schizophrenia. NOS1AP regulates neuronal nitric oxide synthase, which controls intracellular calcium levels and may influence insulin secretion.
View Article and Find Full Text PDFWe aimed to explore the potential link of maternal age at menarche (mAAM) gene polymorphisms with risk of the fetal growth restriction (FGR). This case (FGR)-control (FGR free) study included 904 women (273 FGR and 631 control) in the third trimester of gestation examined/treated in the Departments of Obstetrics. For single nucleotide polymorphism (SNP) multiplex genotyping, 50 candidate loci of mAAM were chosen.
View Article and Find Full Text PDFIn this study, the association between maternal age at menarche (AAM)-related polymorphisms and offspring birth weight (BW) was studied. The work was performed on a sample of 716 pregnant women and their newborns. All pregnant women underwent genotyping of 50 SNPs of AAM candidate genes.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores how genetic variations influencing the glutamatergic neurotransmitter system impact the development and clinical symptoms of schizophrenia in 805 Russian patients from Siberia.
- - Three specific gene variants (rs11644461, rs8057394, rs7313149) are linked to a particular type of schizophrenia, with the rs8057394*G allele identified as a risk factor for this type.
- - Additionally, another variant (rs62126236) shows a protective effect against negative symptoms, while overall symptom severity is significantly associated with yet another variant (rs9788936), indicating the role of genetic factors in schizophrenia's clinical diversity.
Article Synopsis
- Metabolic syndrome is common among schizophrenia patients on long-term antipsychotic treatment, which can result from the effects of dopamine D2 receptors.
- The study analyzed 517 schizophrenia patients in Siberia, focusing on two specific genetic variations in the DRD2 gene and their link to metabolic syndrome.
- Findings suggest that a particular variation (rs1799732) is associated with drug-induced metabolic syndrome in women, pointing to the potential for targeted genetic treatments to improve patient outcomes.