Publications by authors named "A V Boĭko"
Article Synopsis
- Transmembrane integrin-associated protein is shown to be a significant checkpoint in innate immunity that is elevated in cancer cells like melanoma, impacting anti-tumor responses.
- Research utilized ATAC-Sequencing to uncover increased chromatin accessibility in the promoter region of this protein in melanoma versus normal cells.
- The study identified the transcription factor NRF-1 as a key regulator binding to specific sites in the promoter region, which is crucial for the protein's upregulation during tumor progression.
Military conflicts, terrorist attacks and wars around the world pose a wide range of questions to the medical community about providing medical care to military personnel and civilians with mine-explosive trauma, which is characterized by simultaneous damage of various anatomical areas, including the maxillofacial region. The purpose of this work was to describe a case from practice of treating a patient with a mine-explosive trauma, which manifested by a fracture of the right zygomatic-orbital complex and the upper jaw on the right. Using own case from practice, the authors showed that the treatment of patients with mine-explosive trauma of the maxillofacial region is long-term, multi-stage and should take place in a specialized hospital with the involvement of a team of multidisciplinary specialists.
View Article and Find Full Text PDFOne of the fundamental problems in studying addiction is elucidation of mechanisms of alcohol dependence (AD) development. Disturbances of cellular redox balance and inflammation play an important role in AD pathogenesis. Deciphering associations between biological and clinical indicators can elucidate molecular mechanisms of disease pathogenesis.
View Article and Find Full Text PDFPatients with systemic lupus erythematosus (SLE) are known to frequently suffer from comorbid cardiovascular diseases (CVDs). There are abundant data on cytokine levels and their role in the pathogenesis of SLE, while growth factors have received much less attention. The aim of this study was to analyze growth factor levels in SLE patients and their association with the presence of comorbid CVDs.
View Article and Find Full Text PDF[Growth factors PDGF-AA, PDGF-BB and BDNF as potential differentiating biomarkers of unipolar and bipolar depression].
Zh Nevrol Psikhiatr Im S S Korsakova
October 2024
Objective: To establish the differences and identify the prognostic value of biological markers - platelet growth factors PDGF-AA, PDGF-BB and brain-derived neurotrophic growth factor (BDNF) - for the differential diagnosis of patients with unipolar and bipolar depression using machine learning.
Material And Methods: The study included 79 patients aged 48 [34; 57] years, including 35 people with bipolar depression (ICD-10. F31) and 44 people with unipolar depression (F32-33).