[MODERN APPROACHES TO THE DIAGNOSIS AND TREATMENT OF CHEMOTHERAPY TOXICITY IN PATIENTS WITH BREAST CANCER].

The use of modern chemotherapy (CT) allowed to achieve significant progress in the treatment of many malignant tumors that were previously considered fatal. Improving the efficiency of the treatment was achieved by the intensification of chemotherapy. However, intensification of chemotherapy regimes provoked increase in the number of side effects of anticancer therapy,which often lead to a decrease in the intensity of the selected mode, the additional financial costs of treating the complications and the formation of the negative attitude of the patient to treatment.

[Hepatotoxicity of cytostatic drugs in treatment of oncology patients].

A hepatotoxicity can be observed at the use of different groups of antitumoral drugs. Cytotoxicity drugs have a leading place in relation to incidence and severity of liver damage. During chemotherapy the development of hepatotoxicity is caused by thedamage of the liver parenchymal cells with fatty degeneration, necrosis of the liver tissue, and cholestasis.

[The toxic effects of chemotherapy on the gastrointestinal tract].

In modern oncology chemotherapy (CT), along with the surgical technique and radiotherapy is a leader in the treatment of cancer patients. More than 60% of patients receiving chemotherapy at different stages of treatment. Recently, modern chemotherapy has become more urgent personal approach to the choice of drugs and their doses, aimed at reducing the toxicity of chemotherapy.

[Modern principles of chemotherapy of metastatic breast cancer].

Treatment of patients with metastatic breast cancer is one of the most difficult problems of clinical oncology. Chemotherapy is one of the main methods of treatment of patients with metastatic breast cancer. Long experience of the world's cancer centers, advances in clinical oncology recent decades, the synthesis of anticancer drugs with new mechanisms of action have led to progress in the treatment of disseminated breast cancer.