Publications by authors named "A V Artiukhov"
The risk of developing diabetes and cardiometabolic disorders is associated with increased levels of alpha-aminoadipic acid and disturbances in the metabolism of branched-chain amino acids. The side effects of the widely used antidiabetic drug metformin include impaired degradation of branched-chain amino acids and inhibition of intracellular thiamin transport. These effects may be interconnected, as thiamine deficiency impairs the functioning of thiamine diphosphate (ThDP)-dependent dehydrogenases of 2-oxo acids involved in amino acids degradation, while diabetes is often associated with perturbed thiamine status.
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- - Charcot-Marie-Tooth (CMT) neuropathy is a genetic disorder affecting peripheral nerves, with thiamine (vitamin B1) potentially improving symptoms; this study explores thiamine’s effects when taken daily.
- - Patients showed improved hand grip strength with thiamine and its derivatives (sulbutiamine and benfotiamine), but no significant differences in thiamine-related blood levels were found compared to healthy controls.
- - Interestingly, while thiamine raised grip strength, it also reduced certain enzyme levels (holo-transketolase) in CMT patients, and the way transketolase was activated by thiamine differed between the CMT group and controls, highlighting complex
Article Synopsis
- Epilepsy is linked to an imbalance between the neurotransmitters glutamate and GABA, leading to increased seizure activities in the brain, which were analyzed using a rat model during pharmacological kindling with PTZ.
- Post-seizure findings showed significant changes, including increased levels of p53 and decreased activity in the 2-oxoglutarate dehydrogenase complex, impacting glutamate degradation and leading to protein acetylation changes.
- The administration of vitamins B1 and B6 influenced these biochemical parameters, modifying correlations between seizure severity and neurotransmitter levels, suggesting potential neuroprotective effects against epilepsy-related seizures.