[Modern issues of improving the prognosis in patients with atrial fibrillation after ischemic stroke].

The anticoagulant therapy with a priority of direct oral anticoagulants is an approach to the prevention of recurrent stroke in patients with atrial fibrillation (AF) that has presently proved its efficacy and is stated in international clinical guidelines. An extensive evidence-based database demonstrates advantages of rivaroxaban over other drugs of this class in secondary prevention of stroke in AF. Furthermore, these advantages are combined with the optimal safety profile.

[60 years towards definition of dyscirculatory (vascular) encephalopathy: can we put new wine into old wineskins?].

The term 'dyscirculatory encephalopathy' (DEP) was proposed in 1958 by Garun Maksudov and Vladimir Kogan for the definition of gradually progressive diffuse brain changes with slowly worsening of cerebral circulation ('dyscirculation') in vascular disorders. The article presents current data on the etiology and pathogenesis of DEP, with the emphasis on its syndromal status, clinical/pathogenetic types of DEP, neuropsychological and neuroimaging signs, which provide a causal relationship to avoid hyperdiagnosis of DEP. In addition, possible methods of treatment and prevention of DEP are considered.

[Neuroimaging and molecular biomarkers of dementia].

Development of laboratory diagnosis and neuroimaging revealed a number of biomarkers for in vivo diagnosis of the most common forms of dementia (Alzheimer's disease, Lewy body dementia and vascular dementia). Currently, the highest diagnostic sensitivity and specificity of molecular biomarkers in the cerebrospinal fluid are detected for Alzheimer's disease. At the same time, the changes according to the magnetic resonance imaging are more prognostically significant for future cognitive decline than cerebrospinal fluid biomarkers.

[Clinical and neuropsychological features of Alzheimer's disease in the combination with cerebrovascular disease].

Aim: To study clinical/neuropsychological and neuroimaging characteristics of Alzheimer's disease in the combination with cerebrovascular disease (CVD).

Material And Methods: Ninety patients with dementia, including 35 patients with AD, 35 patients with mixed dementia (MD) and 20 patients with vascular dementia, were examined. The character of dementia was established according to NINCDS-ADRDA and NINDS-AIREN criteria.