[The effect of internal course intake of selenium-modified mineral water on bone mineral density after long-term diet-induced metabolic disorders in the experiment. (Randomized controlled trial)].

Introduction: The phenomenon of therapeutic and prophylactic effect of natural mineral waters (MW) used to restore tissue tolerance to glucose and normalize basal insulin secretion in metabolic syndrome is well known. At the same time, the use of selenium-enriched MW is promising due to its multitarget action including participation in the regulation of the protein-synthesizing function of cells.

Aim: To study the effect of internal course intake of selenium-modified mineral waters of different composition on bone mineral density after long-term diet-induced metabolic disorders in the experiment.

[EXPERIMENTAL JUSTIFICATION OF CORRECTIVE ACTION OF NATIVE AND SELENIUM-MODIFIED MINERAL WATERS ON METABOLIC SYNDROME MODEL].

The purpose of the study was to determine the effect of native and selenium-modified mineral waters on metabolic syndrome models. Combined metabolic syndrome (combMS) was simulated in 70 white rats of male gender under standard vivarium conditions, using high-calorie food and single administration of streptozotocin. During the random sampling study the following groups of animals were formed: in the control group 1 (n=6) the rats had standard forage during the experiment; in the control group 2 (n=10) there were rats with combMS model without treatment; in the main groups, starting at the 61st day of combMS, the rats received: the 1st group (n=11) - Essentuki mineral water №4; the 2nd (n=16) - the same water with selenium; in the 3rd (n=11) - Slavyanovskaya mineral water; in the 4th (n=16) - Slavyanovskaya with selenium.

[Evaluation of the influence of different physical and chemical composition mineral waters on the state of carbohydrate metabolism in experimental metabolic syndrome].

Unlabelled: Purpose of the study. To carry out a comparative analysis of the intake effect of mineral waters (MW) of various physicochemical compositions, including those ones enriched in selenium, on the pathogenesis of metabolic syndrome (MS) in the experiment.

Materials And Methods: The experiment was carried out on 68 male white rats aged 3 months, which were divided into 5 groups.

[Investigation of the metabolic effects of selenium-modified Essentuki mineral water in the experiment].

Background: The urgent tasks of experimental balneology are to design and investigate of the action of native mineral waters (MW) enriched with essential trace elements in order to improve their therapeutic and prophylactic effects.

Objective: To investigate the mechanisms of direct action of the cycle intake of Essentuki MWs modified with selenium (Essentuki Novaya - MW1, Essentuki No. 4 - MW2) on healthy animals.

[The evaluation of the effectiveness of the application of bischofite-modified yellow clay (an experimental studi)].

Background: The topical problems in balneotherapeutics and health resort activities in general are the development of the yellow clay-based preparations enriched in the natural mineral bischofite and the investigation of their therapeutic effects with the purpose of improvement of their curative potential.

Aim: The objective of the present study was to evaluate the effectiveness of the course of the experimental therapeutic applications of the yellow clay obtained by the open pit mining of its deposits located in the vicinity of Pyatigorsk and modified by the addition of bischofite.

Material And Methods: The experiments were carried out with the use of 57 eugamic Wistar male rats with adjuvant arthritis.