Publications by authors named "A V Abramova"
Article Synopsis
- The study examined how prenatal stress affects behavior, metabolism, and cytokine levels in male and female rats at various developmental stages after their mothers experienced stress during pregnancy.* -
- Altered correlations between behavioral and metabolic parameters were found in prenatally stressed males at an earlier age than in controls, while female rats showed changing relationships by 60 days old.* -
- Findings indicated that stress reorganizes the connections between metabolic and immune responses, which are vital for behavior, with notable differences based on the offspring's sex and their developmental stage.*
Background: Assembly of metagenomic samples can provide essential information about the mobility potential and taxonomic origin of antibiotic resistance genes (ARGs) and inform interventions to prevent further spread of resistant bacteria. However, similar to other conserved regions, such as ribosomal RNA genes and mobile genetic elements, almost identical ARGs typically occur in multiple genomic contexts across different species, representing a considerable challenge for the assembly process. Usually, this results in many fragmented contigs of unclear origin, complicating the risk assessment of ARG detections.
View Article and Find Full Text PDFThe effects of silver nanoparticles (AgNPs), both alone and in combination with mineral nutrients, on the growth and photosynthesis of Solanum lycopersicum plants during ontogeny were studied. The experiment involved weekly applications of 10 μmol of AgNPs for 15 weeks in a greenhouse over a summer period. A comprehensive characterization of the AgNPs was performed via TEM, ESI/EELS, and zeta potential measurements before and throughout the experiment.
View Article and Find Full Text PDFOxidative stress plays a critical role in numerous pathological processes. Under these stress conditions, the free radical-catalyzed lipid peroxidation generates in vivo a large number of key products that are involved in many physiological and pathophysiological processes. Among these products are neuroprostanes, which arise from the peroxidation of docosahexaenoic acid (DHA), and isoprostanes, resulting from arachidonic acid (AA) and eicosapentaenoic acid (EPA) through the same peroxidation process.
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- Traditional genomic profiling of Circulating Tumor Cells (CTCs) misses important protein alterations affecting treatment efficacy, leading to the development of the ZeptoCTC workflow, which analyzes single cells at the protein level.
- The ZeptoCTC process involves isolating and labeling individual cells, lysing them, and using reverse phase protein array (RPPA) detection for precise protein quantification.
- Results showed ZeptoCTC's effectiveness by revealing significant protein expression differences in CTCs from breast cancer patients and its ability to differentiate based on genetic variants, enhancing understanding of tumor behavior.