Publications by authors named "A Uygun"
Association of Biopsy-proven Nonalcoholic Fatty Liver Disease with Obesity and Apolipoproteins.
J Gastrointestin Liver Dis
December 2024
Background And Aims: Insulin resistance is considered the most important key mechanism in the development of nonalcoholic fatty liver disease (NAFLD). Some studies have reported that hyperinsulinemia decreases the hepatic secretion of apolipoprotein (Apo) B. Chronic hyperinsulinemia in NAFLD may be responsible for the accumulation of triglycerides in hepatocytes.
View Article and Find Full Text PDFComparison of biocompatibility of epoxy resin and bioceramic-based root canal sealers.
Clin Oral Investig
December 2024
Article Synopsis
- The study aimed to compare the cytotoxicity of two bioceramic-based root canal sealers (Bioserra and AH Plus Bio) and two epoxy resin-based sealers (Sealart and AH Plus) on Saos-2 cells.
- Researchers used various methods including the MTT assay for metabolic activity, qRT-PCR to measure gene expression, and western blotting for protein analysis, alongside assessing oxidative stress indicators.
- Results showed AH Plus Bio exhibited the best biocompatibility, while Sealart was the most cytotoxic; Bioserra was generally biocompatible but increased certain gene expressions, indicating a need for careful selection of sealers in dental applications.
Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease and is significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease. NAFLD has become the most prevalent chronic liver disease in Western countries, and the proportion of NAFLD-related cirrhosis among patients on liver transplantation waiting lists has increased. In light of the accumulated data about NAFLD, and to provide a common approach with multi-disciplines dealing with the subject, it has become necessary to create new guidance for diagnosing and treating NAFLD.
View Article and Find Full Text PDFArticle Synopsis
- - Ascochyta rabiei is responsible for causing Ascochyta blight disease on various Cicer species, including C. arietinum and C. bijugum, with field studies revealing significant disease incidences of 32% and 37.3%, respectively, during June 2022 surveys in Turkey.
- - During these surveys, concentric ring-shaped lesions were noted on infected plants, while other Cicer species did not show any disease symptoms, indicating specific susceptibility among the species observed.
- - Laboratory analysis of diseased plant parts led to the successful isolation of fungal strains, with sequencing showing that all 40 isolates were confirmed as belonging to the same species, with certain isolates exhibiting different mating types.
Objectives: To retrospectively compare the overall and event-free survival rates of patients with standard and high risk medulloblastoma who received postoperative radiotherapy (RT) followed by maintenance chemotherapy.
Methods: The study included 48 patients with medulloblastoma who were treated and followed-up between 2005 and 2021. Patients were classified according to the Chang classification because no molecular analysis was done.