Publications by authors named "A Urayama"
Article Synopsis
- Alzheimer's disease (AD) is more prevalent in women than in men, with factors beyond longevity, like metabolic changes, influencing this increased risk.
- A study conducted metabolomic profiling of blood samples from male and female patients with mild cognitive impairment (MCI), revealing significant metabolic differences related to sex, particularly in lipid and peptide energy metabolism pathways.
- The research identified specific metabolites unique to each sex, such as higher levels of 1-palmitoleoyl glycerol in females, suggesting these could be potential biomarkers to enhance our understanding of MCI and AD prevention strategies.
Alzheimer's disease (AD) affects more women than men. Although women live longer than men, it is not longevity alone, but other factors, including metabolic changes, that contribute to the higher risk of AD in women. Metabolic pathways have been implicated in AD progression, but studies to date examined targeted pathways, leaving many metabolites unmeasured.
View Article and Find Full Text PDFBrain functional impairment after stroke is common; however, the molecular mechanisms of post-stroke recovery remain unclear. It is well-recognized that age is the most important independent predictor of poor outcomes after stroke as older patients show poorer functional outcomes following stroke. Mounting evidence suggests that axonal regeneration and angiogenesis, the major forms of brain plasticity responsible for post-stroke recovery, diminished with advanced age.
View Article and Find Full Text PDFArticle Synopsis
- * Aged female mice show greater cognitive deficits and increased signs of cellular aging (senescence) when exposed to iron (ferric citrate) compared to aged male mice.
- * The study identifies the downregulation of the Robo4 receptor in the brain vasculature of aged female mice as a key factor that makes them more vulnerable to iron-induced cellular aging, suggesting it may be a risk factor for brain dysfunction.
Article Synopsis
- The study focuses on the role of G-quadruplex (G4) DNA structures, formed by noncanonical base pairing among guanines, and their impact on gene expression in neurons.
- Researchers used a ligand called pyridostatin (PDS) to stabilize G4 structures, which led to the discovery of 901 differentially expressed genes in neurons, affecting crucial processes like p53 signaling and memory functions.
- The findings highlight a new mechanism involving the E3 ubiquitin ligase Pirh2, which is linked to DNA damage responses and increased G4-DNA levels, suggesting that G4 stabilization may influence both gene regulation and DNA integrity in neurons.