Publications by authors named "A Unlu"
Background: This study aimed to assess the prognostic and predictive implications of CD47, CD68, and CD163, biomarkers of tumor-associated macrophages (TAMs), on the treatment efficacy and clinical outcomes of nasopharyngeal carcinoma (NPC). Additionally, the prognostic value of TAM-related indices, such as the monocyte-to-lymphocyte ratio (MLR) and monocyte-to-albumin ratio (MAR), was evaluated.
Methods: A retrospective cohort of 54 patients with locally advanced or oligometastatic NPC treated with concurrent chemoradiotherapy (CCRT), with or without induction chemotherapy, was analyzed.
Article Synopsis
- The study explored the link between delirium and tryptophan (TRP) along with its metabolites in older critically ill patients (aged >60) admitted to an ICU, involving 120 participants.* -
- Results showed that patients with delirium had significantly higher levels of kynurenine (KYN)/TRP and quinolinic acid (QA)/TRP ratios and lower TRP levels compared to those without delirium, with the KYN/TRP ratio being a strong predictor for delirium.* -
- The findings suggest that measuring tryptophan and its metabolites within the first 24 hours of ICU admission may help identify patients at high risk for developing delirium.*
Article Synopsis
- This study aimed to evaluate the prognostic significance of the pan-immune-inflammation value (PIV) in patients with advanced pancreatic cancer, using a sample of 71 patients predominantly treated with the FOLFIRINOX regimen.
- The results showed that high PIV values significantly correlated with increased mortality and poorer survival outcomes, with median overall survival being 9 months for high PIV patients compared to 26 months for those with lower values.
- The findings suggest that PIV can serve as a valuable prognostic biomarker for patient outcomes in advanced pancreatic cancer and highlight the need for further research to confirm these results.
Purpose: To evaluate the prognostic effects of apparent diffusion coefficient (ADC) values, qualitative MRI findings, and XRCC1 polymorphism in patients with pancreatic ductal adenocarcinoma (PDAC).
Methods: Between January 2019 and December 2021, 41 PDAC patients (23 males; 66.6 ± 8.