Publications by authors named "A Underwood"
Impact of Social Determinants of Health on Pre-exposure Prophylaxis Care for HIV Prevention.
J Acquir Immune Defic Syndr
January 2025
Background: HIV continues to disproportionately impact men who have sex with men (MSM) in the United States (US). Pre-exposure prophylaxis (PrEP) is effective, but disparities persist. Limited studies have conducted systematic evaluations of social determinants of health (SDOH) and their effects on PrEP persistence among MSM.
View Article and Find Full Text PDFPurpose: To examine the implementation and effectiveness of a contraception care intervention for adolescents hospitalized with psychiatric disorders.
Methods: This prospective, observational, hybrid type 2 effectiveness-implementation study examined the effectiveness of the Contraception Care at the Behavioral Health Pavilion (CC@BHP) intervention in 4 inpatient psychiatric units at a quaternary children's hospital. A multifaceted implementation blueprint guided implementation.
Article Synopsis
- The evolution of SARS-CoV-2 has resulted in several variants of concern (VOCs), especially omicron sub-lineages, which display resistance to neutralizing antibodies from past infections or vaccinations.
- In this study, researchers created various mutant viruses with spike protein changes from VOCs like omicron JN.1, and analyzed their resistance to neutralization using plasma from recovered and vaccinated individuals.
- Findings revealed that while specific changes in the spike receptor binding domain contribute to resistance, alterations outside this region are also important; additionally, some omicron variants showed a reduced reliance on the ACE2 receptor for viral entry but maintained increased binding affinity for it.
The continuous emergence of SARS-CoV-2 variants of concern has rendered many therapeutic monoclonal antibodies (mAbs) ineffective. To date, there are no clinically authorized therapeutic antibodies effective against the recently circulating Omicron sub-lineages BA.2.
View Article and Find Full Text PDFAs of 2024, SARS-CoV-2 continues to propagate and drift as an endemic virus, impacting healthcare for years. The largest sequencing initiative for any species was initiated to combat the virus, tracking changes over time at a full virus base-pair resolution. The SARS-CoV-2 sequencing represents a unique opportunity to understand selective pressures and viral evolution but requires cross-disciplinary approaches from epidemiology to functional protein biology.
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