Publications by authors named "A U Pokhrel"

Bacteria often attach to surfaces and grow densely-packed communities called biofilms. As biofilms grow, they expand across the surface, increasing their surface area and access to nutrients. Thus, the overall growth rate of a biofilm is directly dependent on its "range expansion" rate.

View Article and Find Full Text PDF

Objectives: On October 4, 2021, a cholera outbreak was reported in Kapilvastu District, one of Nepal's 26 districts bordering India. This study examined the outbreak's characteristics, response efforts, and the challenges faced.

Methods: A descriptive cross-sectional design was applied for the outbreak investigation.

View Article and Find Full Text PDF

There has been much interest about how to identify an ice core signal for oxidizing capacity of the troposphere. This study broadly explains the air-snow transfer/deposition process using ice core records of dicarboxylic (DCAs), ω-oxocarboxylic as well as pyruvic acids and α-dicarbonyls, which are potentially formed by atmospheric oxidation of aromatic hydrocarbons from the continent, incloud-oxidation of isoprene and unsaturated fatty acids from the western North Pacific. An ice core (~152 m long, 304 years) was collected at an ice cap on the Gorshkov crater at the summit of Ushkovsky (56° 04'N, 160° 28'E, altitude: 3903 m) in the Kamchatka Peninsula from southeastern Siberia.

View Article and Find Full Text PDF

Introduction: Acute organophosphorus poisoning (AOPP) during pregnancy is uncommon. When complicated by preterm labor, it presents therapeutic dilemmas due to the lack of established guidelines.

Case Presentation: The authors describe a case of a 19-year-old primigravida at 33 weeks of gestation with AOPP.

View Article and Find Full Text PDF
Article Synopsis
  • Small antifungal peptides known as NCR peptides, particularly in legumes like chickpeas, show potential as biofungicides due to their ability to act against fungal pathogens through different mechanisms of action (MoA).
  • The study focused on chickpea NCR13, which can form multiple disulfide bonds; two variants of this peptide, NCR13_PFV1 and NCR13_PFV2, were created, showing different structures and antifungal potency despite having the same amino acid sequence.
  • NCR13_PFV1 was found to be more effective in killing fungal cells and inhibiting protein translation, resulting in better disease control in plants sprayed with it, emphasizing the importance of disulfide bond configuration in peptide
View Article and Find Full Text PDF