Publications by authors named "A U Mbah"
Background: Increased body mass index (BMI) in mid-life is associated with a higher risk of Alzheimer's disease (AD). Neurofibrillary tangles (NFTs), comprised of hyperphosphorylated aggregated tau protein, are the pathological hallmark of neurodegenerative tauopathies including Alzheimer's Disease (AD). The relationship between sex-dependent adiposity in late adulthood and tau NFT pathology remain inconclusive.
View Article and Find Full Text PDFBackground: Microstructure impairments of the limbic tracts are seen in early stages of the Alzheimer's disease (AD) continuum. Sleep disruptions differ between sexes and have been linked with AD. We examined sex differences between measures of limbic white matter tracts and objective sleep parameters in cognitively unimpaired older adults.
View Article and Find Full Text PDFBackground: We evaluated whether baseline differences existed in various plasma Alzheimer's disease (AD) biomarkers in cognitively normal participants racialized as Black or White.
Method: This cross-sectional study included 203 (n=83 non-Hispanic Black [NHB] and n=120 non-Hispanic White [NHW]) cognitively unimpaired older adults from the NYU Alzheimer's Disease Research Center. Of the 203, 115 (39NHB, 76 NHW) had tau-PET (PI-2620/MK-6240) data; 195 (85 NHB, 110 NHW) had amyloid-PET (florbetaben); 98 (39 NHB, 59 NHW) had plasma Aβ40 and Ab42 data, 93 (37 NHB, 56 NHW) had data for total tau, 135 (55 NHB, 80 NHW) had neurofilament light (NfL) and glial fibrillary protein (GFAP) data and 139 (57 NHB, 82 NHW) had pTau181 data.
Background: We examined racial differences between measures of limbic white matter tracts and objective sleep parameters in cognitively unimpaired older-adults.
Method: This cross-sectional study included 170 community-dwelling cognitively unimpaired older-adults (mean±SD: age = 67.2±5.
Background: We evaluated whether baseline differences existed in various plasma Alzheimer's disease (AD) biomarkers in cognitively normal participants racialized as Black or White.
Method: This cross-sectional study included 203 (n = 83 non-Hispanic Black [NHB] and n = 120 non-Hispanic White [NHW]) cognitively unimpaired older adults from the NYU Alzheimer's Disease Research Center. Of the 203, 115 (39NHB, 76 NHW) had tau-PET (PI-2620/MK-6240) data; 195 (85 NHB, 110 NHW) had amyloid-PET (florbetaben); 98 (39 NHB, 59 NHW) had plasma Aß40 and Ab42 data, 93 (37 NHB, 56 NHW) had data for total tau, 135 (55 NHB, 80 NHW) had neurofilament light (NfL) and glial fibrillary protein (GFAP) data and 139 (57 NHB, 82 NHW) had pTau181 data.