This study aimed to compare and evaluate the growth inhibition effects of eight previously synthesized compounds, cis-3,4-diaryl-α-methylene-γ-butyrolactams (compounds 1-8), on two human renal carcinoma cell (RCC) lines: CRL-1932 (rapid growth) and HTB-44 (slow growth). MTT assays and flow cytometry were conducted, revealing that compounds 5 and 6 had the potential to induce cell death in the slow-growing RCC cells (HTB-44), while compound 8 demonstrated effectiveness in both RCC lines (HTB-44 and CRL-1932). Additionally, a non-transformed HEK293 cell line and a transgenic zebrafish with a green fluorescent kidney Tg(wt1b:egfp) were used to assess the toxicities of compounds 5, 6, and 8.
View Article and Find Full Text PDFBackground: Plasma biomarkers have recently emerged to detect symptomatic Alzheimer Disease (AD), but have yet to be validated in preclinical AD populations, where Aβ accumulates in the brain but older adults are cognitively unimpaired (CU). In addition to AD pathologic plasma biomarkers (amyloid and tau), inflammatory markers can accurately detect symptomatic AD. We used pathologic and inflammatory plasma biomarkers to predict amyloid PET status in CU older adults.
View Article and Find Full Text PDFBackground: Neuritic plaques with fibrillar beta-amyloid (Aβ) peptides and tau-protein neurofibrillary tangles, hallmark features of Alzheimer's disease (AD) pathology, have been concomitantly associated with white matter (WM) integrity loss, while a unique effect of each pathology on WM integrity in a more demographically diverse population remains unknown.
Method: To examine the degree to which each pathology affects WM integrity in a more diverse non-demented cohort, Aβ and tau PET, diffusion-weighted imaging (DWI), and cognition (memory and executive function composites) were examined from the U.S.
Background: Caring for people with dementia in communities inevitably brings heavy burden for their family caregivers. Senses of positive aspects from caring and proper service support may help shape a healthy care journey for carers. This study aims to evaluate the caregiving burden, positive aspects, and service utilization of informal caregivers for community-living older adults with neurocognitive disorders (NCDs).
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