The efficacy of psychological interventions on well-being during the perinatal period: A systematic review.

Although research has already shown the importance of promoting well-being during pregnancy and after birth, previous meta-analyses on the effectiveness of psychological interventions do not include wellbeing as a primary outcome measure, focusing instead on assessing the effectiveness in reducing symptoms. This study aimed at conducting a systematic review of the effects of psychological interventions on well-being during the perinatal period. A search was conducted in Psycinfo, PubMed, Web of Science (WOS) and Scopus for articles published from 2014 to 2024.

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation.

Tau pathology in sporadic Alzheimer's disease (AD) follows a distinct pattern, beginning in the entorhinal cortex (ERC) and spreading to interconnected brain regions. Early-stage tau pathology, characterized by soluble phosphorylated tau, is difficult to study in human brains post-mortem due to rapid dephosphorylation. Rhesus macaques, which naturally develop age-related tau pathology resembling human AD, provide an ideal model for investigating early tau etiology.

Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer.

Exomer is a protein complex that facilitates trafficking between the Golgi and the plasma membrane (PM). exomer is composed of Cfr1 and Bch1, and we have found that full activation of the cell integrity pathway (CIP) in response to osmotic stress requires exomer. In the wild-type, the CIP activators Rgf1 (Rho1 GEF) and Pck2 (PKC homologue) and the MEK kinase Mkh1 localize in the PM, internalize after osmotic shock and re-localize after adaptation.

Increased Cardiometabolic Risk in Dynapenic Obesity: Results from the Study of Workers' Health (ESAT).

The coexistence of obesity and low muscle strength-denoted dynapenic obesity (DO)-has been associated with an unhealthy metabolic profile and increased risk for metabolic syndrome. However, there is a lack on studies investigating if DO exhibits higher cardiometabolic risk than non-dynapenic obesity. To assess if individuals with DO exhibit elevated cardiometabolic risk compared to non-dynapenic obesity.