Publications by authors named "A Tysarowski"
Background: The phosphoinositide 3-kinase (PI3K) pathway is activated in multiple cancers. However, the significance of encoding the PI3K regulatory subunit, an inhibitor of the PI3K catalytic subunit encoded by , in ovarian cancer development is largely unknown.
Methods: Here, we investigated genomic alterations and gene expression by direct sequencing and qPCR methods in 197 ovarian cancers.
Time from approval to reimbursement recommendations in healthcare systems with centralized HTA processes. Focus on the Polish HTA agency.
Expert Rev Pharmacoecon Outcomes Res
October 2024
Article Synopsis
- - The study analyzed the time it takes for drugs registered by the EMA from 2014 to 2019 to receive reimbursement recommendations in Poland and 11 other countries.
- - Results showed that Poland had a significantly longer time from drug registration to recommendation compared to other countries, although many countries are trending towards faster recommendations between 2014 and 2019.
- - The findings indicate potential improvements in the processes of health authorities and data providers, with Poland experiencing a yearly decrease in the time for reimbursement recommendations despite starting from a longer baseline.
Advances in the diagnosis and treatment of adrenocortical carcinoma (ACC), along with the development of new therapeutic and diagnostic methods, have prompted a team of experts to formulate the first Polish guidelines for managing ACC. This article presents the diagnostic and therapeutic recommendations resulting from the discussion of specialists from various medical specialities, who participated in a series of online meetings aimed at developing consistent and effective recommendations under the National Oncology Strategy. These guidelines aim to optimise ACC treatment in Poland through coordinated efforts of multidisciplinary specialist teams, ensuring an effective and modern approach.
View Article and Find Full Text PDFArticle Synopsis
- Genetic testing is now standard for cancer diagnoses, but it's rare to find patients with multiple simultaneous genetic disorders, prompting the need for targeted next-generation sequencing (NGS) and comprehensive evaluations.
- Two sisters with neck tumors were diagnosed with multiple endocrine neoplasia type 2 (MEN2A) and familial paraganglioma syndrome type 1 (FPGL1) after surgery and genetic testing showed specific mutations in the RET and SDHD genes.
- This case highlights the unusual occurrence of multiple hereditary syndromes occurring in related individuals and stresses the importance of thorough genetic assessment in such scenarios.
Interleukin-6 as a Predictive Factor of Pathological Response to FLOT Regimen Systemic Treatment in Locally Advanced Gastroesophageal Junction or Gastric Cancer Patients.
Cancers (Basel)
February 2024
Background: Perioperative treatment is a gold standard in locally advanced gastric cancer or GEJ cancer in the Western population. Unfortunately, the response rate after neoadjuvant chemotherapy (NAC) remains limited. Moreover, there are currently no biomarkers enabling an individual prediction of therapeutic efficacy.
View Article and Find Full Text PDF