Dual Activities of Flower-like Gold-Iron Oxide Nanozyme for Peroxidase-mimicking and Glucose Detection.

Nanozymes, constituting of inorganic nanomaterials, are the sustainable and cost-effective alternatives of the naturally abundant enzymes. For more than a decade, nanozymes have shown astonishingly enhanced enzymatic activity as compared to its naturally occurring counterpart and emerged as a potential platform in biomedical science. The current study reports a novel flower shaped gold-iron oxide nanocomposite prepared via a facile and green solution phase redox mediated synthesis.

Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening.

Recent development of immune checkpoint inhibitors has revolutionized cancer immunotherapy. Although these drugs show dramatic effects on a subset of cancer patients, many other tumors are non-responsive and the pathological mechanism of the resistance is largely unknown. To identify genes underlying anti-PD-1 immunotherapy resistance using a systematic approach, we performed an in vivo genome wide CRISPR screening in lung cancer cells.

Nondirected Ortho C-H Arylation for One-Pot Synthesis of Biaryl Scaffolds via In Situ Generated Mixed Acetal.

Herein, we introduce a mild and efficient method for synthesizing aniline biaryls and unsymmetrical phenol biaryls through iodine-catalyzed coupling of quinone imine ketals (QIKs)/quinonemonoacetals (QMAs) and -naphthols. This approach allows for the unusual formation of ortho-substituted anilines and phenols, valuable in pharmaceuticals and advanced materials but typically difficult to produce. Our method achieves high -selectivity without needing transition metals or external/internal templates.